GCKR

Gene Symbol	GCKR
Entrez Gene	2646
Alt Symbol	FGQTL5, GKRP
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4) regulator
Other Description	glucokinase regulatory protein
Swissprots	Q99522 Q53RY6 Q14397 B4DPQ2 A1L4C2
Accessions	AAP72013 AAY14850 CAA70779 CAB61828 EAX00568 Q14397 AK291846 BAF84535 AK298448 BAG60664 AK303784 BAG64742 AK309599 BC130481 AAI30482 BC130483 AAI30484 CD368544 DA011063 HQ258318 ADR83072 Z48475 CAA88367 XM_011532761 XP_011531063 XM_011532762 XP_011531064 XM_011532763 XP_011531065 NM_001486 NP_001477
Function	Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269\|PubMed:23621087, ECO:0000269\|PubMed:23733961}.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:10456334}. Nucleus {ECO:0000269\|PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269\|PubMed:19643913, ECO:0000269\|PubMed:9570959}.

GCKR (D1W9P) Rabbit mAb - 14328 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Monoclonal
Clone	D1W9P

Western blot analysis of extracts from various liver (positive) and kidney (negative) samples using GCKR (D1W9P) Rabbit mAb (upper) and GAPDH (D16H11) XP ® Rabbit mAb #5174 (lower).

GCKR (B-9) - sc-166841 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

GCKR (G-6): sc-166841. Western blot analysis of GCKR expression in non-transfected: sc-117752 (A) and mouse GCKR transfected: sc-120452 (B) 293T whole cell lysates.

GCKR (H-300) - sc-11416 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

GCKR (H-300) : sc-11416. Western blot analysis of GCKR expression in mouse liver extract.

GCKR (G-6) - sc-74544 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

GCKR (G-6): sc-74544. Western blot analysis of GCKR expression in Hep G2 whole cell lysate.

GCKR (N-19) - sc-6340 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

GCKR (N-19): sc-6340. Western blot analysis of GCKR expression in rat liver extract.

Anti-GCKR antibody - ab65224 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-GCKR antibody (ab65224) at 1/500 dilutionLane 1 : mouse heart cell extractLane 2 : rat heart cell extractLane 3 : rat heart cell extract with immunising peptide

Anti-GCKR antibody - ab87620 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Goat
Clonality	Polyclonal

Anti-GCKR antibody (ab87620) at 0.1 µg/ml + rat liver lysate (in RIPA buffer) at 35 µg

Anti-GCKR antibody - ab154120 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-GCKR antibody (ab154120) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-GCKR antibody - ab87739 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR antibody (ab87739) at 1 µg/ml + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-GCKR antibody [9G7] - ab118274 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	9G7

All lanes : Anti-GCKR antibody [9G7] (ab118274) at 1/2000 dilutionLane 1 : Non transfected cell lysateLane 2 : GCKR transfected HEK293T cell lysateLysates/proteins at 5 µg per lane.

Anti-GCKR antibody - N-terminal - ab71627 from Abcam

Prices	$359.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR antibody - N-terminal (ab71627) at 1/100 dilution + A375 cell lysate at 12.5 µg

Anti-GCKR Antibody - LS-C155498 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded Normal Colon, using GCKR antibody at 1:500 dilution.

Anti-GCKR Antibody (C-Terminus) - LS-C151543 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

GCKR antibody Western Blot of 721_B cell lysate. GCKR is supported by BioGPS gene expression data to be expressed in 721_B.

Anti-GCKR Antibody (Arg227) - LS-C176813 from LifeSpan Bioscience

Prices	$345.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of GCKR (R227) pAb in extracts from PC12 cells.

Anti-GCKR Antibody (aa91-286) - LS-C294204 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa320-499) - LS-C294207 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa211-260) - LS-C119039 from LifeSpan Bioscience

Prices	$315.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of extracts from mouse heart/rat heart cells, using Glucokinase Regulator Antibody. The lane on the right is treated with the synthesized peptide.

Anti-GCKR Antibody (aa91-286, Biotin) - LS-C297971 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa201-250) - LS-C186732 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Mouse Brain. Gckr antibody dilution 1.0 ug/ml.

Anti-GCKR Antibody (aa320-499, Biotin) - LS-C299846 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa320-499, FITC) - LS-C304072 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa91-286, FITC) - LS-C305334 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-GCKR Antibody (aa5-18) - LS-C112829 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

GCKR antibody (0.1 ug/ml) staining of Rat Liver lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-GCKR Antibody (clone 9G7) - LS-C172503 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	9G7

Anti-GCKR mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY GCKR.

Anti-GCKR Antibody (aa90-286) - LS-C314243 from LifeSpan Bioscience

Prices	$425.00
Sizes	200 µg
Host	Mouse
Clonality	Monoclonal

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