GCKR

Gene Symbol GCKR
Entrez Gene 2646
Alt Symbol FGQTL5, GKRP
Species Human
Gene Type protein-coding
Description glucokinase (hexokinase 4) regulator
Other Description glucokinase regulatory protein
Swissprots Q99522 Q53RY6 Q14397 B4DPQ2 A1L4C2
Accessions AAP72013 AAY14850 CAA70779 CAB61828 EAX00568 Q14397 AK291846 BAF84535 AK298448 BAG60664 AK303784 BAG64742 AK309599 BC130481 AAI30482 BC130483 AAI30484 CD368544 DA011063 HQ258318 ADR83072 Z48475 CAA88367 XM_011532761 XP_011531063 XM_011532762 XP_011531064 XM_011532763 XP_011531065 NM_001486 NP_001477
Function Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269|PubMed:19643913, ECO:0000269|PubMed:9570959}.

GCKR CRISPR/Cas9 KO Plasmid (h) - sc-401623 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR HDR Plasmid (h) - sc-401623-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR Double Nickase Plasmid (h) - sc-401623-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR Double Nickase Plasmid (h2) - sc-401623-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR CRISPR Activation Plasmid (h) - sc-401623-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR CRISPR Activation Plasmid (h2) - sc-401623-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR Lentiviral Activation Particles (h) - sc-401623-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR Lentiviral Activation Particles (h2) - sc-401623-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

GCKR siRNA (h) - sc-35460 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GCKR shRNA Plasmid (h) - sc-35460-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

GCKR shRNA (h) Lentiviral Particles - sc-35460-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU120941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9190 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9190 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01734 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01734

GCKR siRNA (Human) - CRH1760 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

GCKR - MBS8212417 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human GCKR (NM_001486.3) - SHH300034 from Creative biogene

Category siRNA
Species Reactivities Human

GCKR shRNA Plasmid (Human) - CHH1760 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

GCKR miRNA 3'UTR clone - MiUTR3H-03671 from Creative biogene

Species Reactivities Human
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