GCKR

Gene Symbol	GCKR
Entrez Gene	2646
Alt Symbol	FGQTL5, GKRP
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4) regulator
Other Description	glucokinase regulatory protein
Swissprots	Q99522 Q53RY6 Q14397 B4DPQ2 A1L4C2
Accessions	AAP72013 AAY14850 CAA70779 CAB61828 EAX00568 Q14397 AK291846 BAF84535 AK298448 BAG60664 AK303784 BAG64742 AK309599 BC130481 AAI30482 BC130483 AAI30484 CD368544 DA011063 HQ258318 ADR83072 Z48475 CAA88367 XM_011532761 XP_011531063 XM_011532762 XP_011531064 XM_011532763 XP_011531065 NM_001486 NP_001477
Function	Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269|PubMed:19643913, ECO:0000269|PubMed:9570959}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-GCKR-cDNA-Clone - DC14666 from Abgent, a WuXi AppTec company Prices $843.75 Sizes 10 µg Species Human Accession BC130481

GCKR - MBS1278926 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC130481

Human GCKR Gene ORF cDNA clone in cloning vector - HG15700-G from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15700-NF from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15700-ACR from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15700-ANR from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15700-ANG from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-His tag - HG15700-CH from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-His tag - HG15700-NH from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-HA tag - HG15700-CY from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15700-CF from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15700-NM from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15700-CM from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15700-ACG from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid - HG15700-UT from Sino Biological Species Human

Human GCKR Gene ORF cDNA clone expression plasmid, N-HA tag - HG15700-NY from Sino Biological Species Human

Human GCKR ORF clone (NM_001486.3) - CDCL111019 from Creative biogene Species Human

Human GCKR ORF Clone (BC130481) - CDCS410294 from Creative biogene Species Human Accession Q14397

Human GCKR ORF clone (BC130481) - CDCB157943 from Creative biogene Species Human

Human FGQTL5 Gene - orb143333 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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