| Gene Symbol |
GCKR
|
| Entrez Gene |
2646
|
| Alt Symbol |
FGQTL5, GKRP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
glucokinase (hexokinase 4) regulator
|
| Other Description |
glucokinase regulatory protein
|
| Swissprots |
Q99522 Q53RY6 Q14397 B4DPQ2 A1L4C2
|
| Accessions |
AAP72013 AAY14850 CAA70779 CAB61828 EAX00568 Q14397 AK291846 BAF84535 AK298448 BAG60664 AK303784 BAG64742 AK309599 BC130481 AAI30482 BC130483 AAI30484 CD368544 DA011063 HQ258318 ADR83072 Z48475 CAA88367 XM_011532761 XP_011531063 XM_011532762 XP_011531064 XM_011532763 XP_011531065 NM_001486 NP_001477
|
| Function |
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
|
| Tissue Specificity |
Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269|PubMed:19643913, ECO:0000269|PubMed:9570959}.
|
![Western Blot: GCKR Overexpression Lysate (Adult Normal) [NBL1-11010] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GCKR.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7945_GCKR%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11010-img0002.jpg)