GCKR

Gene Symbol	GCKR
Entrez Gene	2646
Alt Symbol	FGQTL5, GKRP
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4) regulator
Other Description	glucokinase regulatory protein
Swissprots	Q99522 Q53RY6 Q14397 B4DPQ2 A1L4C2
Accessions	AAP72013 AAY14850 CAA70779 CAB61828 EAX00568 Q14397 AK291846 BAF84535 AK298448 BAG60664 AK303784 BAG64742 AK309599 BC130481 AAI30482 BC130483 AAI30484 CD368544 DA011063 HQ258318 ADR83072 Z48475 CAA88367 XM_011532761 XP_011531063 XM_011532762 XP_011531064 XM_011532763 XP_011531065 NM_001486 NP_001477
Function	Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6- phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. {ECO:0000269|PubMed:23621087, ECO:0000269|PubMed:23733961}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GKRP associates with GCK and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Found in liver and pancreas. Not detected in muscle, brain, heart, thymus, intestine, uterus, adipose tissue, kidney, adrenal, lung or spleen. {ECO:0000269|PubMed:19643913, ECO:0000269|PubMed:9570959}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human GCKR peptide - ab97365 from Abcam Category Peptide

GCKR Antibody Blocking Peptide - LS-E23234 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCKR Antibody Blocking Peptide - LS-E23233 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCKR Antibody Blocking Peptide - LS-E27030 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GCKR blocking peptide - GTX88432-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

Human GCKR protein - orb244820 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

GCKR Blocking Peptide - abx062122 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

Human GKRP Protein - abx066790 from Abbexa Category Protein Source E.coli Species Human

Human GKRP Protein - abx066791 from Abbexa Category Protein Source E.coli Species Human

GCKR Peptide - AC21-1853-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Glucokinase Regulatory Protein (GKRP), Human - 20-7671 from ARP American Research Products Category Protein Prices $609.00 Sizes 50 µg Source E.coli Species Human

Glucokinase Regulatory Protein (GKRP), Human - 20-7672 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

GCKR Peptide - 46-981P from ProSci Category Peptide Species Mouse, Rat

Recombinant Glucokinase Regulatory Protein (GKRP) - RPB365Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Glucokinase Regulatory Protein (GKRP) - RPB365Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Glucokinase Regulatory Protein (GKRP) - RPB365Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

Recombinant Glucokinase Regulatory Protein (GKRP) - RPB365Ra02 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

GCKR Blocking Peptide - CBP3228 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

GCKR (R227) Peptide - BS2059P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Mitogen Activated Protein Kinase Kinase Kinase Kinase 5 (MAP4K5) - RPB135Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Glucokinase Regulatory Protein (GKRP) - RPB365Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Glucokinase regulatory protein(GCKR) - CSB-YP622767HU CSB-BP622767HU CSB-MP622767HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Glucokinase regulatory protein - CSB-EP622767HU from Cusabio Category Protein Source E.coli Species Human

GCKR (1-300) - sc-4501 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

GCKR Protein - abx164189 from Abbexa Category Protein Species Human, Mouse, Rat

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