VCL

Gene Symbol	VCL
Entrez Gene	7414
Alt Symbol	CMD1W, CMH15, HEL114, MV, MVCL
Species	Human
Gene Type	protein-coding
Description	vinculin
Other Description	epididymis luminal protein 114|metavinculin
Swissprots	Q8IXU7 Q16450 Q7Z3B8 P18206 Q5SWX2
Accessions	AAA61271 AAB21656 AAB21657 EAW54547 EAW54548 EAW54549 EAW54550 EAW54551 P18206 AA368699 AI290052 AK126978 BAG54414 AK296509 BAG59141 AK300280 BAG62039 AK304823 BAG65571 AL700886 AL708715 AL832130 BC013847 BC039174 AAH39174 BX537994 CAD97952 DQ894680 ABM85606 EU794673 ACJ13727 M33308 AAA61283 XM_005270142 XP_005270199 XM_005270143 XP_005270200 NM_003373 NP_003364 NM_014000 NP_054706
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18439753}. Cell junction, adherens junction {ECO:0000269|PubMed:18439753}. Cell membrane {ECO:0000269|PubMed:18439753}; Peripheral membrane protein {ECO:0000269|PubMed:18439753}; Cytoplasmic side {ECO:0000269|PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269|PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.
Tissue Specificity	Metavinculin is muscle-specific.
Top Pathways	Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse VCL / Vinculin ELISA Kit (Sandwich ELISA) - LS-F5890 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.128 ng/ml Range 15.6-1000 pg/ml

Human VCL / Vinculin ELISA Kit (Sandwich ELISA) - LS-F5016 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 15.6 pg/ml Range 15.6-1000 pg/ml

Human VCL / Vinculin ELISA Kit (Sandwich ELISA) - LS-F12953 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 15.6-1000 pg/ml

Measlesvirus (MV) antibody ( IgG), Human, ELISA Kit - CSB-E05000h from ARP American Research Products Category ELISA Kit Prices $425.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Measlesvirus (MV) antibody ( IgM ), Human, ELISA Kit - CSB-E05001h from ARP American Research Products Category ELISA Kit Prices $425.00, $615.00, $616.00, $619.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Vinculin, VCL, Human, ELISA Kit - E-EL-H1795 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 46.875 Range 78.125-5000pg/mL

Vinculin (VCL), Human, ELISA Kit - CSB-EL025812HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 7.03 pg/ml Range 28.12 pg/ml-1800 pg/ml

Vinculin (VCL), Human, ELISA Kit - SEB839Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 32pg/mL Range 78-5,000pg/mL

Vinculin, Human, ELISA Kit - E01V0025 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 1.0ng/ml Range 5.0-100ng/ml

Vinculin, VCL, Human, ELISA Kit - E1839h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 1.56-100 ng/mL

Vinculin, VCL, Rabbit, ELISA Kit - E-EL-RB1425 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Vinculin, VCL, Chicken, ELISA Kit - E-EL-Ch1181 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Vinculin, VCL, Porcine, ELISA Kit - E-EL-P1236 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Vinculin, VCL, Guinea Pig, ELISA Kit - E-EL-GP0615 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Vinculin, VCL, Monkey, ELISA Kit - E-EL-MK1380 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Measles Virus (MV) - K804 from ARP American Research Products Category PCR Kit Prices $949.00 Sizes 100 reactions

Human VCL ELISA Kit - HV0032 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine VCL ELISA Kit - AV0032 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human VCL(Vinculin) ELISA Kit - E-EL-H1795 from Elabscience Category ELISA Kit Sensitivity 46.88 pg/mL Range 78.13—5000 pg/mL

Human VCL (Vinculin) CLIA Kit - E-CL-H1117 from Elabscience Category CLIA Kit Sensitivity 9.38 pg/mL Range Average Recovery (%)

VCL, ELISA Kit - MBS2508105 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.344pg/mL Range 3.906-250pg/mL

VCL, ELISA Kit - MBS2506615 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.344pg/mL Range 3.906-250pg/mL

VCL, ELISA Kit - MBS2500276 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of Human VCL is 46.875pg/mL Range 78.125-5000pg/mL

VCL, ELISA Kit - MBS2503123 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

VCL, ELISA Kit - MBS2506734 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 46.875pg/mL Range 78.125-5000pg/mL

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