VCL

Gene Symbol VCL
Entrez Gene 7414
Alt Symbol CMD1W, CMH15, HEL114, MV, MVCL
Species Human
Gene Type protein-coding
Description vinculin
Other Description epididymis luminal protein 114|metavinculin
Swissprots Q8IXU7 Q16450 Q7Z3B8 P18206 Q5SWX2
Accessions AAA61271 AAB21656 AAB21657 EAW54547 EAW54548 EAW54549 EAW54550 EAW54551 P18206 AA368699 AI290052 AK126978 BAG54414 AK296509 BAG59141 AK300280 BAG62039 AK304823 BAG65571 AL700886 AL708715 AL832130 BC013847 BC039174 AAH39174 BX537994 CAD97952 DQ894680 ABM85606 EU794673 ACJ13727 M33308 AAA61283 XM_005270142 XP_005270199 XM_005270143 XP_005270200 NM_003373 NP_003364 NM_014000 NP_054706
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
Subcellular Location Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18439753}. Cell junction, adherens junction {ECO:0000269|PubMed:18439753}. Cell membrane {ECO:0000269|PubMed:18439753}; Peripheral membrane protein {ECO:0000269|PubMed:18439753}; Cytoplasmic side {ECO:0000269|PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269|PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.
Tissue Specificity Metavinculin is muscle-specific.
Top Pathways Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis

VCL 293 Cell Lysate - 408746 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

Vinculin Overexpression Lysate (Native) - NBL1-17706 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Vinculin Overexpression Lysate (Adult Normal) [NBL1-17706] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Vinculin.

vinculin (h): 293T Lysate - sc-113822 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

VCL Over-expression Lysate Product - GWB-B1C990 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Human VCL / Vinculin HEK293 Cell Lysate (WB positive control) - 10019-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human VCL Human Cells Transfected Lysate (positive control) (denatured) - orb174023 from Biorbyt

Category Cell Lysate
Prices $425.00
Sizes 300 μg
Species Human

Panoply™ Human VCL Knockdown Stable Cell Line - CSC-DC017251 from Creative biogene

Category Cell Line
Species Human
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