VCL

Gene Symbol	VCL
Entrez Gene	7414
Alt Symbol	CMD1W, CMH15, HEL114, MV, MVCL
Species	Human
Gene Type	protein-coding
Description	vinculin
Other Description	epididymis luminal protein 114|metavinculin
Swissprots	Q8IXU7 Q16450 Q7Z3B8 P18206 Q5SWX2
Accessions	AAA61271 AAB21656 AAB21657 EAW54547 EAW54548 EAW54549 EAW54550 EAW54551 P18206 AA368699 AI290052 AK126978 BAG54414 AK296509 BAG59141 AK300280 BAG62039 AK304823 BAG65571 AL700886 AL708715 AL832130 BC013847 BC039174 AAH39174 BX537994 CAD97952 DQ894680 ABM85606 EU794673 ACJ13727 M33308 AAA61283 XM_005270142 XP_005270199 XM_005270143 XP_005270200 NM_003373 NP_003364 NM_014000 NP_054706
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18439753}. Cell junction, adherens junction {ECO:0000269|PubMed:18439753}. Cell membrane {ECO:0000269|PubMed:18439753}; Peripheral membrane protein {ECO:0000269|PubMed:18439753}; Cytoplasmic side {ECO:0000269|PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269|PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.
Tissue Specificity	Metavinculin is muscle-specific.
Top Pathways	Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Vinculin full length protein - ab131747 from Abcam Category Protein Source Wheat germ Species Human

Human Vinculin full length protein - ab151336 from Abcam Category Protein Source E. coli Species Human

Human Vinculin peptide - ab74076 from Abcam Category Peptide

Human Vinculin protein fragment - ab126002 from Abcam Category Protein Source E. coli Species Human

VCL / Vinculin Antibody Blocking Peptide - LS-E22334 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VCL / Vinculin Antibody Blocking Peptide - LS-E8947 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

VCL / Vinculin Antibody Blocking Peptide - LS-E8946 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Vinculin Protein - H00007414-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Vinculin-Antibody-C-term-Blocking-peptide - BP7426b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

VINC-Antibody-N-term-Blocking-Peptide - BP7426a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Vinculin (OPCA01000) - OPCA01000 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

Human VCL protein (His Tag) - orb139852 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells Species Human

Human VCL protein - orb245568 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

VCL Blocking Peptide - 33R-7332 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

VCL protein - 30R-3278 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Human Vinculin Protein - abx069667 from Abbexa Category Protein Source E.coli Species Human

Vinculin (VCL) - H00007414-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Vinculin (VCL) - H00007414-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Vinculin (VCL), Human - 20-8075 from ARP American Research Products Category Protein Prices $485.00 Sizes 50 µg Source E.coli Species Human

Vinculin, Human, Recombinant - 19-C264 from ARP American Research Products Category Protein Prices $169.00 Sizes 10 µg Source E. coli Species Human

Vinculin Peptide - 7809P from ProSci Category Peptide Species Human

Vinculin Peptide - 7489P from ProSci Category Peptide Species Human

Vinculin Peptide (8B5) - PM-7813P from ProSci Category Peptide Species Human

Vinculin Peptide [7E10] - PM-7811P from ProSci Category Peptide Species Human

Vinculin fusion protein - Ag3705 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

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