VCL

Gene Symbol	VCL
Entrez Gene	7414
Alt Symbol	CMD1W, CMH15, HEL114, MV, MVCL
Species	Human
Gene Type	protein-coding
Description	vinculin
Other Description	epididymis luminal protein 114|metavinculin
Swissprots	Q8IXU7 Q16450 Q7Z3B8 P18206 Q5SWX2
Accessions	AAA61271 AAB21656 AAB21657 EAW54547 EAW54548 EAW54549 EAW54550 EAW54551 P18206 AA368699 AI290052 AK126978 BAG54414 AK296509 BAG59141 AK300280 BAG62039 AK304823 BAG65571 AL700886 AL708715 AL832130 BC013847 BC039174 AAH39174 BX537994 CAD97952 DQ894680 ABM85606 EU794673 ACJ13727 M33308 AAA61283 XM_005270142 XP_005270199 XM_005270143 XP_005270200 NM_003373 NP_003364 NM_014000 NP_054706
Function	Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269|PubMed:20484056}.
Subcellular Location	Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18439753}. Cell junction, adherens junction {ECO:0000269|PubMed:18439753}. Cell membrane {ECO:0000269|PubMed:18439753}; Peripheral membrane protein {ECO:0000269|PubMed:18439753}; Cytoplasmic side {ECO:0000269|PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269|PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.
Tissue Specificity	Metavinculin is muscle-specific.
Top Pathways	Adherens junction, Focal adhesion, Leukocyte transendothelial migration, Bacterial invasion of epithelial cells, Amoebiasis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human VCL gene - orb90641 from Biorbyt Prices $672.00 Sizes 10 μg Species Human

VCL - MBS1278748 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC039174

Human VCL cDNA clone(NM_003373.3) - CDFH021039 from Creative Biomart Species Human Accession NM_003373.3

Human VCL cDNA clone(NM_014000.2) - CDFH021040 from Creative Biomart Species Human Accession NM_014000.2

human VCL ORF clone - CDCH099322 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099323 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099324 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099325 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099326 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099327 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099328 from Creative Biomart Species Human Accession NM_003373

human VCL ORF clone - CDCH099329 from Creative Biomart Species Human Accession NM_003373

Human VCL ORF Clone(NM_003373.3) - CDCL180852 from Creative Biomart Species Human Accession NM_003373.3

Human VCL ORF Clone(NM_003373.3) - CDCR285344 from Creative Biomart Species Human Accession NM_003373.3

Human VCL ORF Clone(NM_003373.3) - CDCR285345 from Creative Biomart Species Human Accession NM_003373.3

Human VCL ORF Clone(NM_014000.2) - CDCR296734 from Creative Biomart Species Human Accession NM_014000.2

Human VCL ORF Clone(NM_014000.2) - CDCR296735 from Creative Biomart Species Human Accession NM_014000.2

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone in cloning vector - HG10019-M from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10019-NM from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10019-CM from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10019-M-F from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, N-His tag - HG10019-NH from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10019-ACR from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10019-ANR from Sino Biological Species Human

Human VCL/Vinculin transcript variant 2 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10019-ANG from Sino Biological Species Human

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