Gene Symbol | PRAF2 |
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Entrez Gene | 11230 |
Alt Symbol | JM4 |
Species | Human |
Gene Type | protein-coding |
Description | PRA1 domain family, member 2 |
Other Description | Jena-Muenchen 4|PRA1 family protein 2 |
Swissprots | O60831 B2RD20 |
Accessions | EAW50706 EAW50707 O60831 AA720948 AJ005896 CAA06753 AK023433 BAG51191 AK310550 AK315374 BAG37767 BC021213 AAH21213 CB155577 CR457023 CAG33304 NM_007213 NP_009144 |
Function | May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis. {ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}. |
Subcellular Location | Endosome membrane {ECO:0000305|PubMed:17975142}; Multi-pass membrane protein {ECO:0000305|PubMed:17975142}. |
Tissue Specificity | Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. {ECO:0000269|PubMed:16481131, ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}. |
JM4 (G-14) - sc-168228 from Santa Cruz Biotechnology
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JM4 (N-14) - sc-168229 from Santa Cruz Biotechnology
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Anti-JM4 antibody - ab53113 from Abcam
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Anti-JM4 antibody - ab40167 from Abcam
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Anti-JM4 antibody - ab97897 from Abcam
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Anti-PRAF2 Antibody (aa165-178) - LS-C50433 from LifeSpan Bioscience
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Anti-PRAF2 Antibody (aa141-190) IHC-plus⢠- LS-B11118 from LifeSpan Bioscience
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Anti-PRAF2 Antibody (aa129-178) IHC-plus⢠- LS-B8388 from LifeSpan Bioscience
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JM4 Antibody - NBP1-87886 from Novus Biologicals
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JM4 Antibody - NB100-91835 from Novus Biologicals
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Anti-PRAF2 antibody produced in rabbit - HPA002859 from Sigma-Aldrich
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Anti-JM4, C-Terminal antibody produced in rabbit - SAB4500234 from Sigma-Aldrich
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JM4-Antibody - AP50707 from Abgent, a WuXi AppTec company
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JM4 antibody - GTX87370 from GeneTex
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PRAF2 Antibody (OAAB18502) - OAAB18502 from Aviva Systems Biology
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PRAF2 Antibody (OAAF01840) - OAAF01840 from Aviva Systems Biology
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Anti-JM4 Antibody (OAAI00578) - OAAI00578 from Aviva Systems Biology
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JM4 Antibody - abx013118 from Abbexa
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JM4 Antibody - abx011373 from Abbexa
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PRAF2 Antibody - abx008275 from Abbexa
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JM4 / PRAF2 (165-178) antibody - AP15613PU-M from Acris Antibodies
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JM4 / PRAF2 (165-178) antibody - AP15613PU-N from Acris Antibodies
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JM4 / PRAF2 (165-178) antibody - AP15613PU-S from Acris Antibodies
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JM4 / PRAF2 antibody - AP06190PU-N from Acris Antibodies
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JM4 / PRAF2 (C-term) antibody - AP32236PU-N from Acris Antibodies
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