PRAF2

Gene Symbol	PRAF2
Entrez Gene	11230
Alt Symbol	JM4
Species	Human
Gene Type	protein-coding
Description	PRA1 domain family, member 2
Other Description	Jena-Muenchen 4\|PRA1 family protein 2
Swissprots	O60831 B2RD20
Accessions	EAW50706 EAW50707 O60831 AA720948 AJ005896 CAA06753 AK023433 BAG51191 AK310550 AK315374 BAG37767 BC021213 AAH21213 CB155577 CR457023 CAG33304 NM_007213 NP_009144
Function	May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis. {ECO:0000269\|PubMed:17975142, ECO:0000269\|PubMed:18395978}.
Subcellular Location	Endosome membrane {ECO:0000305\|PubMed:17975142}; Multi-pass membrane protein {ECO:0000305\|PubMed:17975142}.
Tissue Specificity	Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. {ECO:0000269\|PubMed:16481131, ECO:0000269\|PubMed:17975142, ECO:0000269\|PubMed:18395978}.

Category	Cell Line
Species	Human

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