Gene Symbol | PRAF2 |
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Entrez Gene | 11230 |
Alt Symbol | JM4 |
Species | Human |
Gene Type | protein-coding |
Description | PRA1 domain family, member 2 |
Other Description | Jena-Muenchen 4|PRA1 family protein 2 |
Swissprots | O60831 B2RD20 |
Accessions | EAW50706 EAW50707 O60831 AA720948 AJ005896 CAA06753 AK023433 BAG51191 AK310550 AK315374 BAG37767 BC021213 AAH21213 CB155577 CR457023 CAG33304 NM_007213 NP_009144 |
Function | May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis. {ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}. |
Subcellular Location | Endosome membrane {ECO:0000305|PubMed:17975142}; Multi-pass membrane protein {ECO:0000305|PubMed:17975142}. |
Tissue Specificity | Strong expression in the brain, small intestine, lung, spleen, and pancreas as well as in tumor tissues of the breast, colon, lung and ovary, with a weaker expression in normal tissues of the same patient. High expression in neuroblastic tumors. Strongly expressed in Purkinje cells and more moderately in cells of the molecular and the granular layers in the cerebellum. Detected in neuronal cells, but not in non- neuronal cells in the cerebral cortex, hippocampus, and lateral ventricles. {ECO:0000269|PubMed:16481131, ECO:0000269|PubMed:17975142, ECO:0000269|PubMed:18395978}. |
JM4 CRISPR/Cas9 KO Plasmid (h) - sc-407211 from Santa Cruz Biotechnology
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JM4 HDR Plasmid (h) - sc-407211-HDR from Santa Cruz Biotechnology
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JM4 Double Nickase Plasmid (h) - sc-407211-NIC from Santa Cruz Biotechnology
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JM4 Double Nickase Plasmid (h2) - sc-407211-NIC-2 from Santa Cruz Biotechnology
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JM4 CRISPR Activation Plasmid (h) - sc-407211-ACT from Santa Cruz Biotechnology
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JM4 CRISPR Activation Plasmid (h2) - sc-407211-ACT-2 from Santa Cruz Biotechnology
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JM4 Lentiviral Activation Particles (h) - sc-407211-LAC from Santa Cruz Biotechnology
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JM4 Lentiviral Activation Particles (h2) - sc-407211-LAC-2 from Santa Cruz Biotechnology
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JM4 siRNA (h) - sc-91097 from Santa Cruz Biotechnology
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JM4 shRNA Plasmid (h) - sc-91097-SH from Santa Cruz Biotechnology
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JM4 shRNA (h) Lentiviral Particles - sc-91097-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU130681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17334 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17334 from Sigma-Aldrich
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PRAF2 siRNA (Human) - CRH7696 from Cohesion Biosciences
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shRNA set against Human PRAF2 (NM_007213.1) - SHH381856 from Creative biogene
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shRNA set against Human PRAF2(NM_007213.1) - SHR136446 from Creative biogene
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Human PRAF2 siRNA - orb268198 from Biorbyt
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PRAF2 shRNA Plasmid (Human) - CHH7696 from Cohesion Biosciences
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PRAF2 miRNA 3'UTR clone - MiUTR1H-08210 from Creative biogene
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