ANG

Gene Symbol ANG
Entrez Gene 283
Alt Symbol ALS9, HEL168, RAA1, RNASE4, RNASE5
Species Human
Gene Type protein-coding
Description angiogenin, ribonuclease, RNase A family, 5
Other Description RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Swissprots P03950 Q8WXE7 Q53X86 Q05CV1 Q6P5T2
Accessions AAA51678 AAL67710 AAL67711 AAL67712 AAL67713 AAL67714 CDG31911 EAW66450 EAW66451 P03950 AK313989 BAG36701 AV646929 BC020704 AAH20704 BC054880 AAH54880 BC062698 AAH62698 BQ773604 CB157060 CB963791 CR407633 CAG28561 FJ236304 ACI45236 HQ447651 ADQ32136 NM_001097577 NP_001091046 NM_001145 NP_001136
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.

ANG-Over-expression-Lysate - LY12282a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ANG (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ANG gene

ANG I (h): CHO Lysate - sc-110020 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

Angiogenin Overexpression Lysate (Native) - NBP2-11430 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Angiogenin Overexpression Lysate (Adult Normal) [NBP2-11430] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Angiogenin.

Angiogenin Overexpression Lysate (Native) - NBP2-10954 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Angiogenin Overexpression Lysate (Adult Normal) [NBP2-10954] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Angiogenin.

Angiogenin Overexpression Lysate (Native) - NBP2-10950 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Angiogenin Overexpression Lysate (Adult Normal) [NBP2-10950] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Angiogenin.

Panoply™ Human ANG Knockdown Stable Cell Line - CSC-DC000588 from Creative biogene

Category Cell Line
Species Human
Search more