ANG

Gene Symbol	ANG
Entrez Gene	283
Alt Symbol	ALS9, HEL168, RAA1, RNASE4, RNASE5
Species	Human
Gene Type	protein-coding
Description	angiogenin, ribonuclease, RNase A family, 5
Other Description	RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Swissprots	P03950 Q8WXE7 Q53X86 Q05CV1 Q6P5T2
Accessions	AAA51678 AAL67710 AAL67711 AAL67712 AAL67713 AAL67714 CDG31911 EAW66450 EAW66451 P03950 AK313989 BAG36701 AV646929 BC020704 AAH20704 BC054880 AAH54880 BC062698 AAH62698 BQ773604 CB157060 CB963791 CR407633 CAG28561 FJ236304 ACI45236 HQ447651 ADQ32136 NM_001097577 NP_001091046 NM_001145 NP_001136
Function	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity	Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Angiogenin peptide - ab107903 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Angiogenin full length protein - ab114413 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human Angiogenin full length protein - ab151351 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

Human Angiogenin full length protein - ab177677 from Abcam Category Protein Prices $301.00 Sizes 100 µg Source E. coli Species Human

Angiogenin / ANG Antibody Blocking Peptide - LS-E31315 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Angiogenin Recombinant Protein - H00000283-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ANG-Antibody-Center-Blocking-peptide - BP10663c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Angiogenin-Fragment-108-123 - SP2658a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

Angiogenin-Fragment-108-122 - SP2657a from Abgent, a WuXi AppTec company Category Peptide Prices $100.00 Sizes 1 mg

Recombinant Human Angiogenin - 265-AN-050 from R&D Systems Category Protein Source E. coli-derived, Gln25-Pro147

Recombinant Human Angiogenin - 265-AN-250 from R&D Systems Category Protein Source E. coli-derived, Gln25-Pro147

Recombinant Human Angiogenin, CF - 265-AN-050/CF from R&D Systems Category Protein Source E. coli-derived, Gln25-Pro147

Recombinant Human Angiogenin, CF - 265-AN-250/CF from R&D Systems Category Protein Source E. coli-derived, Gln25-Pro147

ANG Protein Lysate (APL10392) - APL10392 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ANG Protein Lysate (APL10393) - APL10393 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Recombinant human Angiogenin protein (OPCA00593) - OPCA00593 from Aviva Systems Biology Category Protein Prices $198.00 Sizes 50 µg Species Human

Human RNASE5 protein - orb245248 from Biorbyt Category Protein Prices $315.00, $502.00, $782.00, $1,139.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

angiogenin protein - orb197666 from Biorbyt Category Protein Prices $255.00, $391.00, $519.00 Sizes 10 μg, 50 μg, 100 μg Species Human

Human Angiogenin protein - orb49192 from Biorbyt Category Protein Prices $272.00, $366.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

ANG protein (His tag) - 80R-3737 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Angiogenin protein (His tag) - 80R-3459 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Angiogenin protein (His tag) - 80R-3460 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

ANG Blocking Peptide - abx161013 from Abbexa Category Peptide Species Human, Mouse

Angiogenin (25-147, His-tag) - AR51424PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Angiogenin (25-147, His-tag) - AR51424PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Search more