ANG

Gene Symbol	ANG
Entrez Gene	283
Alt Symbol	ALS9, HEL168, RAA1, RNASE4, RNASE5
Species	Human
Gene Type	protein-coding
Description	angiogenin, ribonuclease, RNase A family, 5
Other Description	RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Swissprots	P03950 Q8WXE7 Q53X86 Q05CV1 Q6P5T2
Accessions	AAA51678 AAL67710 AAL67711 AAL67712 AAL67713 AAL67714 CDG31911 EAW66450 EAW66451 P03950 AK313989 BAG36701 AV646929 BC020704 AAH20704 BC054880 AAH54880 BC062698 AAH62698 BQ773604 CB157060 CB963791 CR407633 CAG28561 FJ236304 ACI45236 HQ447651 ADQ32136 NM_001097577 NP_001091046 NM_001145 NP_001136
Function	Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity	Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Angiogenin gene - orb91025 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human ALS9 Gene - orb145077 from Biorbyt Prices $255.00 Sizes 10 μg Species Human

Human-ANG-cDNA-Clone - DC08024 from Abgent, a WuXi AppTec company Prices $198.45 Sizes 10 µg Species Human Accession BC054880

ANG - MBS1269007 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC054880

ANG - MBS1278246 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC062698

Human ANG ORF clone(NM_001097577.2) - CDCL182680 from Creative Biomart Species Human Accession NM_001097577.2

Human ANG ORF Clone(NM_001145.4) - CDCL153787 from Creative Biomart Species Human Accession NM_001145.4

Human Angiogenin / RNASE5 Gene ORF cDNA clone in cloning vector - HG10441-M from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10441-CM from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10441-ACR from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10441-M-F from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10441-ACG from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, N-His tag - HG10441-NH from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid - HG10441-UT from Sino Biological Species Human

Human Angiogenin Gene cDNA Clone (full-length ORF Clone) expression ready, untagged - HG10441-M-N from Sino Biological Species Human Accession NM_001097577.2

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10441-NF from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10441-NM from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10441-CY from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10441-CF from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10441-NY from Sino Biological Species Human

Human Angiogenin / RNASE5 Gene ORF cDNA clone expression plasmid, C-His tag - HG10441-CH from Sino Biological Species Human

Angiogenin - CL01133H01 from Elabscience Species Human Accession NM_001097577.2

Angiogenin - CL01133H02 from Elabscience Species Human Accession NM_001145.4

Human ANG ORF clone(NM_001097577.2) - CDCL182680 from Creative biogene Species Human

Human ANG ORF Clone (BC054880) - CDCS407393 from Creative biogene Species Human Accession P03950

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