ANG

Gene Symbol ANG
Entrez Gene 283
Alt Symbol ALS9, HEL168, RAA1, RNASE4, RNASE5
Species Human
Gene Type protein-coding
Description angiogenin, ribonuclease, RNase A family, 5
Other Description RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Swissprots P03950 Q8WXE7 Q53X86 Q05CV1 Q6P5T2
Accessions AAA51678 AAL67710 AAL67711 AAL67712 AAL67713 AAL67714 CDG31911 EAW66450 EAW66451 P03950 AK313989 BAG36701 AV646929 BC020704 AAH20704 BC054880 AAH54880 BC062698 AAH62698 BQ773604 CB157060 CB963791 CR407633 CAG28561 FJ236304 ACI45236 HQ447651 ADQ32136 NM_001097577 NP_001091046 NM_001145 NP_001136
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.

ANG I (C-1) - sc-74528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ANG I (C-1): sc-74528. Western blot analysis of ANG I expression in non-transfected (A) and human ANG I transfected (B) CHO whole cell lysates.

ANG I (H-123) - sc-9044 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
ANG I (H-123): sc-9044. Western blot analysis of ANG I expression in non-transfected: sc-117750 (A) and human ANG I transfected: sc-110020 (B) CHO whole cell lysates.

ANG I (C-20) - sc-1408 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ANG I (C-20): sc-1408. Western blot analysis of human recombinant ANG I.

ANG I (K-20) - sc-27264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ANG I (T-20) - sc-20866 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Angiogenin antibody - ab139947 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescence of Angiogenin in Human liver tissue with ab139947 at 20 ug/mL.

Anti-Angiogenin antibody - ab189207 from Abcam

Prices $384.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Angiogenin antibody (ab189207) at 1 µg/mlLane 2 : Anti-Angiogenin antibody (ab189207) at 2 µg/mlLane 1 : rat liver tissue lysateLane 2 : rat liver tissue lysatedeveloped using the ECL technique

Anti-Angiogenin antibody - ab95389 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Angiogenin antibody (ab95389) at 1 µg/mlLane 1 : Lung (Human) Tissue Lysate Lane 2 : Liver (Human) Tissue Lysate - adult normal tissue (ab29889)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Angiogenin antibody - ab125231 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Angiogenin antibody (ab125231) at 1 µg/mlLane 1 : MCF7 lysateLane 2 : HeLa lysateLane 3 : SW620 lysate

Anti-Angiogenin antibody - ab107065 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-Angiogenin antibody (ab107065) at 1/100 dilution + Jurkat cell lysate at 35 µg

Anti-Angiogenin antibody [14017.7] - ab10600 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 14017.7
ab10600 staining Angiogenin in murine dermis (including follicle) by Immunohistochemistry (Frozen sections). Tissue was fixed with paraformaldehyde and permeabilized using 0.1% Triton. Samples were then blocked with 10% serum for 1 hour at 19°C followed by incubation with the primary antibody at a 1/500 dilution for 16 hours at 4°C. An Alexa Fluor®555 (red) conjugated donkey anti-mouse polyclonal was used as secondary antibody at a 1/200 dilution. Counterstain DAPI (blue).See Abreview

Anti-Angiogenin / ANG Antibody (aa24-148, FITC) - LS-C302249 from LifeSpan Bioscience

Prices $475.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-Angiogenin / ANG Antibody (HRP) - LS-C318707 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody - LS-C331528 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of mouse liver cell lines, using ANG antibody.

Anti-Angiogenin / ANG Antibody (Internal) IHC-plus™ - LS-B8851 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-Angiogenin / ANG antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-Angiogenin / ANG Antibody - LS-C3690 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Angiogenin / ANG Antibody - LS-C34969 from LifeSpan Bioscience

Prices $415.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody - LS-C125074 from LifeSpan Bioscience

Prices $635.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-Angiogenin / ANG Antibody - LS-C121375 from LifeSpan Bioscience

Prices $740.00
Sizes 150 µg
Host Mouse
Clonality Monoclonal

Anti-Angiogenin / ANG Antibody (clone MANG-1) - LS-C96274 from LifeSpan Bioscience

Prices $495.00
Sizes 150 µg
Host Mouse
Clonality Monoclonal
Clone MANG-1

Anti-Angiogenin / ANG Antibody (HRP) - LS-C212030 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody - LS-C212028 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody (Biotin) - LS-C212033 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody (FITC) - LS-C212032 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Angiogenin / ANG Antibody - LS-C285814 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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