ANG

Gene Symbol ANG
Entrez Gene 283
Alt Symbol ALS9, HEL168, RAA1, RNASE4, RNASE5
Species Human
Gene Type protein-coding
Description angiogenin, ribonuclease, RNase A family, 5
Other Description RNase 5|angiogenin|epididymis luminal protein 168|ribonuclease 5|ribonuclease A A1
Swissprots P03950 Q8WXE7 Q53X86 Q05CV1 Q6P5T2
Accessions AAA51678 AAL67710 AAL67711 AAL67712 AAL67713 AAL67714 CDG31911 EAW66450 EAW66451 P03950 AK313989 BAG36701 AV646929 BC020704 AAH20704 BC054880 AAH54880 BC062698 AAH62698 BQ773604 CB157060 CB963791 CR407633 CAG28561 FJ236304 ACI45236 HQ447651 ADQ32136 NM_001097577 NP_001091046 NM_001145 NP_001136
Function Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo. {ECO:0000269|PubMed:12051708, ECO:0000269|PubMed:1400510, ECO:0000269|PubMed:19354288, ECO:0000269|PubMed:21855800}.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane. Nucleus, nucleolus. Note=Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
Tissue Specificity Expressed predominantly in the liver. Also detected in endothelial cells and spinal cord neurons. {ECO:0000269|PubMed:17886298, ECO:0000269|PubMed:2440105}.

ANG I CRISPR/Cas9 KO Plasmid (h) - sc-401766 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I HDR Plasmid (h) - sc-401766-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I Double Nickase Plasmid (h) - sc-401766-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I Double Nickase Plasmid (h2) - sc-401766-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I CRISPR Activation Plasmid (h) - sc-401766-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I CRISPR Activation Plasmid (h2) - sc-401766-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I Lentiviral Activation Particles (h) - sc-401766-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I Lentiviral Activation Particles (h2) - sc-401766-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ANG I siRNA (h) - sc-39291 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ANG I shRNA Plasmid (h) - sc-39291-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ANG I shRNA (h) Lentiviral Particles - sc-39291-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN3144 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3144 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

ANG siRNA (Human) - CRH0196 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Angiogenin RNAi - H00000283-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ANG - MBS8224730 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ANG (NM_001145.4) - SHH236170 from Creative biogene

Category siRNA
Species Reactivities Human

Human ANG siRNA - orb260698 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ANG shRNA Plasmid (Human) - CHH0196 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ANG miRNA 3'UTR clone - MiUTR3H-00139 from Creative biogene

Species Reactivities Human

ANG miRNA 3'UTR clone - MiUTR3H-00140 from Creative biogene

Species Reactivities Human
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