| Gene Symbol |
TFAP2B
|
| Entrez Gene |
7021
|
| Alt Symbol |
AP-2B, AP2-B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
|
| Other Description |
AP2-beta|activating enhancer binding protein 2 beta|activating enhancer-binding protein 2-beta|transcription factor AP-2-beta
|
| Swissprots |
Q9Y3K3 Q9NU99 Q92481 Q9Y214 Q9NQ63 Q9UJI7 Q5JYX6
|
| Accessions |
CAA71047 CAC01130 EAX04355 EAX04356 EAX04357 Q92481 AK291172 BAF83861 AK313749 BAG36489 AU141084 BC037225 AAH37225 BU738725 DQ891443 ABM82369 DQ894621 ABM85547 X95694 CAA64990 XM_006715176 XP_006715239 XM_006715177 XP_006715240 XM_011514834 XP_011513136 XM_011514835 XP_011513137 XM_011514836 XP_011513138 XM_011514837 XP_011513139 NM_003221 NP_003212
|
| Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|