Gene Symbol | TFAP2B |
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Entrez Gene | 7021 |
Alt Symbol | AP-2B, AP2-B |
Species | Human |
Gene Type | protein-coding |
Description | transcription factor AP-2 beta (activating enhancer binding protein 2 beta) |
Other Description | AP2-beta|activating enhancer binding protein 2 beta|activating enhancer-binding protein 2-beta|transcription factor AP-2-beta |
Swissprots | Q9Y3K3 Q9NU99 Q92481 Q9Y214 Q9NQ63 Q9UJI7 Q5JYX6 |
Accessions | CAA71047 CAC01130 EAX04355 EAX04356 EAX04357 Q92481 AK291172 BAF83861 AK313749 BAG36489 AU141084 BC037225 AAH37225 BU738725 DQ891443 ABM82369 DQ894621 ABM85547 X95694 CAA64990 XM_006715176 XP_006715239 XM_006715177 XP_006715240 XM_011514834 XP_011513136 XM_011514835 XP_011513137 XM_011514836 XP_011513138 XM_011514837 XP_011513139 NM_003221 NP_003212 |
Function | Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia. {ECO:0000269|PubMed:11694877}. |
Subcellular Location | Nucleus {ECO:0000305}. |
AP-2β siRNA (h) - sc-37687 from Santa Cruz Biotechnology
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AP-2β shRNA Plasmid (h) - sc-37687-SH from Santa Cruz Biotechnology
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AP-2β shRNA (h) Lentiviral Particles - sc-37687-V from Santa Cruz Biotechnology
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AP-2 beta/TFAP2B RNAi - H00007021-R01 from Novus Biologicals
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MISSION® esiRNA - EHU059961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21245 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21245 from Sigma-Aldrich
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TFAP2B siRNA (Human) - CRH4796 from Cohesion Biosciences
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TFAP2B - MBS8202194 from MyBioSource
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shRNA set against Human TFAP2B (NM_003221.3) - SHH426088 from Creative biogene
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shRNA set against Human TFAP2B(NM_003221.3) - SHL066744 from Creative biogene
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Human TFAP2B siRNA - orb265298 from Biorbyt
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TFAP2B shRNA Plasmid (Human) - CHH4796 from Cohesion Biosciences
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TFAP2B miRNA 3'UTR clone - MiUTR1H-10336 from Creative biogene
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