KRT18

Gene Symbol KRT18
Entrez Gene 3875
Alt Symbol CYK18, K18
Species Human
Gene Type protein-coding
Description keratin 18, type I
Other Description CK-18|cell proliferation-inducing gene 46 protein|cell proliferation-inducing protein 46|cytokeratin 18|cytokeratin-18|keratin, type I cytoskeletal 18|keratin-18
Swissprots P05783 Q9BW26 Q53G38 Q5U0N8
Accessions AAA59461 CBU30436 CBU83085 EAW96655 EAW96656 P05783 AK129587 AK223093 BAD96813 AK308506 AK313988 BAG36700 AY762101 AAX07828 BC000180 AAH00180 BC000698 AAH00698 BC004253 AAH04253 BC008636 AAH08636 BC009754 AAH09754 BC020982 AAH20982 BC072017 AAH72017 BG753529 BT019412 AAV38219 CD106591 DQ890555 ABM92172 DQ893715 ABM84641 L32537 AAA73889 X12876 CAA31369 X12881 CAA31375 X12883 CAA31377 NM_000224 NP_000215 NM_199187 NP_954657
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
Subcellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus.
Tissue Specificity Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2422083, ECO:0000269|PubMed:2434380, ECO:0000269|PubMed:2434381}.
Top Pathways Pathogenic Escherichia coli infection

Pan-Keratin (C11) Mouse mAb (PE Conjugate) - 5075 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone C11
Flow cytometric analysis of MCF7 cells using Pan Keratin (C11) Mouse mAb (PE Conjugate) (blue) compared to concentration matched Mouse (G3A1) mAb IgG1 Isotype Control (PE Conjugate) #6899 (red).

Pan-Keratin (C11) Mouse mAb (Biotinylated) - 4279 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone C11
Western blot analysis of extracts from HeLa and H-4-II-E cells using Pan-Keratin (C11) Mouse mAb (Biotinylated) detected using Streptavidin-HRP #3999.

Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 555 Conjugate) - 3478 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone C11
Confocal immunofluorescent analysis of MCF7 cells using Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 555 Conjugate) (red). Blue pseudocolor = DRAQ5 ® #4084 (fluoresent DNA dye).

Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 647 Conjugate) - 4528 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone C11
Confocal immunofluorescent analysis of paraffin-embedded SK-OV-3 xenograft using Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 647 Conjugate) (blue). Red= Propidium iodide (PI)/RNase Staining Solution.

Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 488 Conjugate) - 4523 from Cell Signaling Technology

Prices $299.00
Sizes 100 µl (50 tests)
Host Mouse
Clonality Monoclonal
Clone C11
Confocal immunofluorescent analysis of MCF-7 cells using Pan-Keratin (C11) Mouse mAb (Alexa Fluor ® 488 Conjugate) (green). Blue pseudocolor = DRAQ5 ® #4084 (fluorescent DNA dye).

Pan-Keratin (C11) Mouse mAb - 4545 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone C11
Western blot analysis of extracts from various cell lines, using Pan-Keratin (C11) Mouse mAb.

Keratin 8/18 (C51) Mouse mAb - 4546 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone C51
Western blot analysis of extracts from various cell lines, using Keratin 8/18 (C51) Mouse mAb.

Keratin 18 (DC10) Mouse mAb - 4548 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (20 western blots)
Host Mouse
Clonality Monoclonal
Clone DC10
Western blot analysis of extracts from HeLa and A431 cells, using Keratin 18 (DC10) Mouse mAb.

Cytokeratin 5 (RCK103) - sc-32721 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 5 (RCK103): sc-32721. Western blot analysis of Cytokeratin 5 expression in Hep G2 whole cell lysate.

Cytokeratin 5/8 (RCK102) - sc-32328 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 5/8 (RCK102): sc-32328. Western blot analysis of Cytokeratin 5/8 expression in Hep G2 whole cell lysate.

Cytokeratin 5/8 (C50) - sc-8021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 5/8 (C50): sc-8021. Western blot analysis of Cytokeratin 5/8 expression in Hep G2 whole cell lysate.

Cytokeratin 5/8 (5F295) - sc-70928 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 5/8 (5F295): sc-70928. Western blot analysis of Cytokeratin 5/8 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (RGE53) - sc-32329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (RGE53): sc-32329. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (B-6) - sc-398871 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (B-6): sc-398871. Western blot analysis of Cytokeratin 18 expression in MCF7 (A), HeLa (B), A-431 (C), Hep G2 (D) and ECV304 (E) whole cell lysates.

Cytokeratin 18 (DC-10) - sc-6259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (DC-10): sc-6259. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tumor showing cytoskeletal staining of hepatocytes.

Cytokeratin 18 (RCK106) - sc-32722 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (RCK106): sc-32722. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (H-80) - sc-28264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Cytokeratin 18 (H-80): sc-28264. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (N-16) - sc-31700 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Cytokeratin 18 (N-16): sc-31700. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (P-14) - sc-31701 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Cytokeratin 18 (C-04) - sc-51582 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (C-04): sc-51582. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (B23.1.) - sc-58727 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (B23.1.): sc-58727. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (LDK18) - sc-53256 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (LDK18): sc-53256. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 15/18 (LC18N) - sc-53254 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Cytokeratin 18 (2X44) - sc-70917 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (2X44): sc-70917. Western blot analysis of Cytokeratin 18 expression in Hep G2 whole cell lysate.

Cytokeratin 18 (DA-7) - sc-51583 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Cytokeratin 18 (C-04): sc-51582. Western blot analysis of Cytokeratin 18 expression in non-transfected: sc-110760 (A) and human Cytokeratin 18 transfected: sc-112918 (B) 293 whole cell lysates.
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