KRT18

Gene Symbol	KRT18
Entrez Gene	3875
Alt Symbol	CYK18, K18
Species	Human
Gene Type	protein-coding
Description	keratin 18, type I
Other Description	CK-18|cell proliferation-inducing gene 46 protein|cell proliferation-inducing protein 46|cytokeratin 18|cytokeratin-18|keratin, type I cytoskeletal 18|keratin-18
Swissprots	P05783 Q9BW26 Q53G38 Q5U0N8
Accessions	AAA59461 CBU30436 CBU83085 EAW96655 EAW96656 P05783 AK129587 AK223093 BAD96813 AK308506 AK313988 BAG36700 AY762101 AAX07828 BC000180 AAH00180 BC000698 AAH00698 BC004253 AAH04253 BC008636 AAH08636 BC009754 AAH09754 BC020982 AAH20982 BC072017 AAH72017 BG753529 BT019412 AAV38219 CD106591 DQ890555 ABM92172 DQ893715 ABM84641 L32537 AAA73889 X12876 CAA31369 X12881 CAA31375 X12883 CAA31377 NM_000224 NP_000215 NM_199187 NP_954657
Function	Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
Subcellular Location	Cytoplasm, perinuclear region. Nucleus, nucleolus.
Tissue Specificity	Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2422083, ECO:0000269|PubMed:2434380, ECO:0000269|PubMed:2434381}.
Top Pathways	Pathogenic Escherichia coli infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cytokeratin 18 full length protein - ab53663 from Abcam Category Protein Source E. coli Species Human

Human Cytokeratin 18 full length protein - ab73638 from Abcam Category Protein Source E. coli Species Human

Human Cytokeratin 18 peptide - ab26325 from Abcam Category Peptide

KRT18 / CK18 / Cytokeratin 18 Antibody Blocking Peptide - LS-E14635 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KRT18 / CK18 / Cytokeratin 18 Antibody Blocking Peptide - LS-E14634 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KRT18 / CK18 / Cytokeratin 18 Antibody Blocking Peptide - LS-E8902 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cytokeratin 18 Protein - H00003875-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cytokeratin 18 Protein - H00003875-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

CYK18-Antibody-C-term-Blocking-Peptide - BP7376b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Keratin, type I cytoskeletal 18 protein (OPCA00878) - OPCA00878 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Recombinant human Keratin, type I cytoskeletal 18 protein (OPCA00879) - OPCA00879 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

KRT18 Protein (OPPA01263) - OPPA01263 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

KRT18 Protein (OPPA02159) - OPPA02159 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Cytokeratin-18 (Western Blot Control) Protein (OPRB00124) - OPRB00124 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

Cytokeratin-18 Protein (OPRB00125) - OPRB00125 from Aviva Systems Biology Category Protein Prices $249.00 Sizes 10 µg

Cytokeratin-18 Protein (OPRB00126) - OPRB00126 from Aviva Systems Biology Category Protein Prices $839.00 Sizes 100 µg

Human KRT18 protein (His Tag) - orb81184 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human KRT18 protein - orb245469 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human KRT18 protein - orb81183 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human KRT18 protein - orb245468 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Cytokeratin 18 Blocking Peptide - 33R-1352 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytokeratin 18 Blocking Peptide - 33R-9270 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytokeratin 18 protein - 30R-AC039 from Fitzgerald Category Protein Prices $335.00, $495.00 Sizes 100 µg, 250 µg Source E.coli

Keratin K18 protein - 30R-2119 from Fitzgerald Category Protein Prices $525.00 Sizes 250 µg Source E.coli

Keratin K18 protein - 30R-2139 from Fitzgerald Category Protein Prices $330.00 Sizes 100 µg Source E.coli

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