KRT18

Gene Symbol KRT18
Entrez Gene 3875
Alt Symbol CYK18, K18
Species Human
Gene Type protein-coding
Description keratin 18, type I
Other Description CK-18|cell proliferation-inducing gene 46 protein|cell proliferation-inducing protein 46|cytokeratin 18|cytokeratin-18|keratin, type I cytoskeletal 18|keratin-18
Swissprots P05783 Q9BW26 Q53G38 Q5U0N8
Accessions AAA59461 CBU30436 CBU83085 EAW96655 EAW96656 P05783 AK129587 AK223093 BAD96813 AK308506 AK313988 BAG36700 AY762101 AAX07828 BC000180 AAH00180 BC000698 AAH00698 BC004253 AAH04253 BC008636 AAH08636 BC009754 AAH09754 BC020982 AAH20982 BC072017 AAH72017 BG753529 BT019412 AAV38219 CD106591 DQ890555 ABM92172 DQ893715 ABM84641 L32537 AAA73889 X12876 CAA31369 X12881 CAA31375 X12883 CAA31377 NM_000224 NP_000215 NM_199187 NP_954657
Function Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. {ECO:0000250, ECO:0000269|PubMed:15529338, ECO:0000269|PubMed:16424149, ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:7523419, ECO:0000269|PubMed:8522591, ECO:0000269|PubMed:9298992, ECO:0000269|PubMed:9524113}.
Subcellular Location Cytoplasm, perinuclear region. Nucleus, nucleolus.
Tissue Specificity Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. {ECO:0000269|PubMed:17213200, ECO:0000269|PubMed:2422083, ECO:0000269|PubMed:2434380, ECO:0000269|PubMed:2434381}.
Top Pathways Pathogenic Escherichia coli infection

Cytokeratin 18 CRISPR/Cas9 KO Plasmid (h) - sc-400305 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 HDR Plasmid (h) - sc-400305-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 Double Nickase Plasmid (h) - sc-400305-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 Double Nickase Plasmid (h2) - sc-400305-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 CRISPR Activation Plasmid (h) - sc-400305-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 CRISPR Activation Plasmid (h2) - sc-400305-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 Lentiviral Activation Particles (h) - sc-400305-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 Lentiviral Activation Particles (h2) - sc-400305-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Cytokeratin 18 siRNA (h) - sc-35151 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cytokeratin 18 shRNA Plasmid (h) - sc-35151-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cytokeratin 18 shRNA (h) Lentiviral Particles - sc-35151-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Cytokeratin 18 RNAi - H00003875-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Cytokeratin 18 RNAi - H00003875-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113871 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU007111 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN11365 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11365 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KRT18 siRNA (Human) - CRH2625 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Cytokeratin 18 - MBS826802 from MyBioSource

Prices $255.00
Sizes 5 od
Species Reactivities Human

shRNA set against Human KRT18(NM_000224.2) - SHL205446 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human KRT18(NM_199187.1) - SHL205464 from Creative biogene

Category siRNA
Species Reactivities Human

Human Cytokeratin 18 siRNA - orb263127 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Cytokeratin 18 siRNA - orb219178 from Biorbyt

Category siRNA
Prices $417.00
Sizes 5 od (260 nm)
Species Reactivities Human

KRT18 shRNA Plasmid (Human) - CHH2625 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

KRT18 miRNA 3'UTR clone - MiUTR1H-05443 from Creative biogene

Species Reactivities Human
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