Gene Symbol | IZUMO1 |
---|---|
Entrez Gene | 284359 |
Alt Symbol | IZUMO |
Species | Human |
Gene Type | protein-coding |
Description | izumo sperm-egg fusion 1 |
Other Description | OBF|izumo sperm-egg fusion protein 1|oocyte binding/fusion factor|sperm-specific protein Izumo |
Swissprots | Q6Q8P6 Q8IYV9 Q6Q8P7 |
Accessions | EAW52395 EAW52396 EAW52397 EAW52398 Q8IYV9 AB195682 BAD91012 AK301750 BAG63212 AY552609 AAS59145 AY552610 AAS59146 BC034769 AAH34769 BC050460 DQ893362 ABM84288 DQ894535 ABM85461 DQ896767 ABM87766 EU176807 ABW03608 XM_005258793 XP_005258850 XM_005258797 XP_005258854 XM_005258798 XP_005258855 XM_011526811 XP_011525113 XM_011526812 XP_011525114 XM_011526813 XP_011525115 XM_011526814 XP_011525116 XM_011526815 XP_011525117 XM_011526816 XP_011525118 XM_011526817 XP_011525119 XR_243923 XR_430196 XR_935799 NM_182575 NP_872381 |
Function | Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Tissue Specificity | Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269|PubMed:15759005}. |
Izumo sperm-egg fusion protein 1, IZUMO1, Human, ELISA Kit - E1556h from ARP American Research Products
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izumo sperm-egg fusion 1, ELISA Kit - MBS9338242 from MyBioSource
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Mouse IZUMO1 / IZUMO ELISA Kit (Custom ELISA) - LS-F17990 from LifeSpan Bioscience
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Rat IZUMO1 / IZUMO ELISA Kit (Custom ELISA) - LS-F17991 from LifeSpan Bioscience
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Human IZUMO1 / IZUMO ELISA Kit (Sandwich ELISA) - LS-F17992 from LifeSpan Bioscience
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IZUMO1 - EKH3626 from Nordic BioSite
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Human IZUMO1 ELISA Kit - E021149 from Biobool
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IZUMO1 ELISA Kit (Human) (OKEH04240) - OKEH04240 from Aviva Systems Biology
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Izumo sperm-egg fusion protein 1, ELISA Kit - MBS761720 from MyBioSource
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Izumo sperm-egg fusion protein 1, ELISA Kit - MBS2882003 from MyBioSource
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Human IZUMO1 / IZUMO ELISA Kit (Sandwich ELISA) - LS-F33836 from LifeSpan Bioscience
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