| Gene Symbol |
IZUMO1
|
| Entrez Gene |
284359
|
| Alt Symbol |
IZUMO
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
izumo sperm-egg fusion 1
|
| Other Description |
OBF|izumo sperm-egg fusion protein 1|oocyte binding/fusion factor|sperm-specific protein Izumo
|
| Swissprots |
Q6Q8P6 Q8IYV9 Q6Q8P7
|
| Accessions |
EAW52395 EAW52396 EAW52397 EAW52398 Q8IYV9 AB195682 BAD91012 AK301750 BAG63212 AY552609 AAS59145 AY552610 AAS59146 BC034769 AAH34769 BC050460 DQ893362 ABM84288 DQ894535 ABM85461 DQ896767 ABM87766 EU176807 ABW03608 XM_005258793 XP_005258850 XM_005258797 XP_005258854 XM_005258798 XP_005258855 XM_011526811 XP_011525113 XM_011526812 XP_011525114 XM_011526813 XP_011525115 XM_011526814 XP_011525116 XM_011526815 XP_011525117 XM_011526816 XP_011525118 XM_011526817 XP_011525119 XR_243923 XR_430196 XR_935799 NM_182575 NP_872381
|
| Function |
Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'. {ECO:0000269|PubMed:15759005}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction. {ECO:0000269|PubMed:15759005}.
|
![Western Blot: IZUMO1 Overexpression Lysate (Adult Normal) [NBL1-12090] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IZUMO1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7388_IZUMO1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12090-img0002.jpg)