EED

Gene Symbol EED
Entrez Gene 8726
Alt Symbol HEED, WAIT1
Species Human
Gene Type protein-coding
Description embryonic ectoderm development
Other Description WD protein associating with integrin cytoplasmic tails 1|polycomb protein EED
Swissprots Q6NTH2 A8K7V5 Q86VV2 Q7LDG8 Q7LDA5 Q9UNY7 O75530 O00149
Accessions CCQ43235 EAW75129 EAW75130 EAW75131 O75530 AA811323 AF070418 AAC23685 AF078933 AAC68675 AF080227 AAC95144 AF099032 AAD08815 AI378297 AK292120 BAF84809 AK294133 BAG57461 AK301265 BAG62829 AL546955 AW263732 BC047672 AAH47672 BC062443 BC068995 AAH68995 DB086430 EU446743 ABZ92272 U90651 AAD08714 XM_005274373 XP_005274430 XM_011545329 XP_011543631 XM_011545330 XP_011543632 XM_011545331 XP_011543633 XR_247215 NM_001308007 NP_001294936 NM_003797 NP_003788 NM_152991 NP_694536
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:9584199}.
Subcellular Location Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Tissue Specificity Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:9584199, ECO:0000269|PubMed:9765275, ECO:0000269|PubMed:9806832, ECO:0000269|PubMed:9880543}.

EED 293T Cell Transient Overexpression Lysate(Denatured) - H00008726-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

EED overexpression lysate - LY401248 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

EED 293 Cell Lysate - 404165 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Tissue Embryo

EED 293 Cell Lysate - 401149 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg
Tissue Embryo

EED Overexpression Lysate (Denatured) - H00008726-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
EED transfected lysate.

EED Overexpression Lysate (Native) - NBL1-10119 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: EED Overexpression Lysate (Adult Normal) [NBL1-10119] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EED.

EED Overexpression Lysate (Native) - NBL1-10120 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: EED Overexpression Lysate (Adult Normal) [NBL1-10120] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EED.

EED Over-expression Lysate Product - GWB-8B1E10 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

EED Over-expression Lysate Product - GWB-1D201F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Human EED / Embryonic Ectoderm Development Insect Cell Lysate (WB positive control) - 11307-H20BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human
Tissue Embryo

Human EED Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175086 from Biorbyt

Category Cell Lysate
Prices $425.00
Sizes 300 μg
Species Human

Panoply™ Human EED Knockdown Stable Cell Line - CSC-DC004722 from Creative biogene

Category Cell Line
Species Human
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