EED

Gene Symbol	EED
Entrez Gene	8726
Alt Symbol	HEED, WAIT1
Species	Human
Gene Type	protein-coding
Description	embryonic ectoderm development
Other Description	WD protein associating with integrin cytoplasmic tails 1|polycomb protein EED
Swissprots	Q6NTH2 A8K7V5 Q86VV2 Q7LDG8 Q7LDA5 Q9UNY7 O75530 O00149
Accessions	CCQ43235 EAW75129 EAW75130 EAW75131 O75530 AA811323 AF070418 AAC23685 AF078933 AAC68675 AF080227 AAC95144 AF099032 AAD08815 AI378297 AK292120 BAF84809 AK294133 BAG57461 AK301265 BAG62829 AL546955 AW263732 BC047672 AAH47672 BC062443 BC068995 AAH68995 DB086430 EU446743 ABZ92272 U90651 AAD08714 XM_005274373 XP_005274430 XM_011545329 XP_011543631 XM_011545330 XP_011543632 XM_011545331 XP_011543633 XR_247215 NM_001308007 NP_001294936 NM_003797 NP_003788 NM_152991 NP_694536
Function	Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:9584199}.
Subcellular Location	Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Tissue Specificity	Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:9584199, ECO:0000269|PubMed:9765275, ECO:0000269|PubMed:9806832, ECO:0000269|PubMed:9880543}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human EZH2 + EED + SUZ12 full length protein - ab196409 from Abcam Category Protein Prices $1,712.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human EED full length protein - ab131946 from Abcam Category Protein Source Wheat germ Species Human

Human EED full length protein - ab156723 from Abcam Category Protein Source E. coli Species Human

Human EED full length protein - ab196104 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human EED peptide - ab13743 from Abcam Category Peptide

Human EED protein fragment - ab112381 from Abcam Category Protein Source Wheat germ Species Human

EED Antibody Blocking Peptide - LS-E31323 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

EED Antibody Blocking Peptide - LS-E12687 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EED Partial Recombinant Protein - H00008726-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

EED Recombinant Protein - H00008726-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human EED Protein - NBP2-23020 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

EED-Antibody-Center-Blocking-Peptide - BP8896c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human EED His GST tag protein - orb84718 from Biorbyt Category Protein Prices $298.00, $612.00 Sizes 20 μg, 100 μg Source Insect Species Human

Human EED protein - orb191285 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

EED protein (His tag) - 80R-2859 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

Polycomb protein EED (1-441, His-tag) - AR50978PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

Polycomb protein EED (1-441, His-tag) - AR50978PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

Polycomb protein EED - H00008726-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Polycomb protein EED - H00008726-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Polycomb protein EED - H00008726-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Polycomb protein EED - H00008726-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Polycomb protein EED (N-term) Control Peptide - AP55487CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EED, 1-441aa, Human, His tag, E.coli - 01-P2154 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

EED Peptide - 7009P from ProSci Category Peptide Species Human

EED fusion protein - Ag10369 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

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