EED

Gene Symbol EED
Entrez Gene 8726
Alt Symbol HEED, WAIT1
Species Human
Gene Type protein-coding
Description embryonic ectoderm development
Other Description WD protein associating with integrin cytoplasmic tails 1|polycomb protein EED
Swissprots Q6NTH2 A8K7V5 Q86VV2 Q7LDG8 Q7LDA5 Q9UNY7 O75530 O00149
Accessions CCQ43235 EAW75129 EAW75130 EAW75131 O75530 AA811323 AF070418 AAC23685 AF078933 AAC68675 AF080227 AAC95144 AF099032 AAD08815 AI378297 AK292120 BAF84809 AK294133 BAG57461 AK301265 BAG62829 AL546955 AW263732 BC047672 AAH47672 BC062443 BC068995 AAH68995 DB086430 EU446743 ABZ92272 U90651 AAD08714 XM_005274373 XP_005274430 XM_011545329 XP_011543631 XM_011545330 XP_011543632 XM_011545331 XP_011543633 XR_247215 NM_001308007 NP_001294936 NM_003797 NP_003788 NM_152991 NP_694536
Function Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:9584199}.
Subcellular Location Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Tissue Specificity Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:9584199, ECO:0000269|PubMed:9765275, ECO:0000269|PubMed:9806832, ECO:0000269|PubMed:9880543}.

EED CRISPR/Cas9 KO Plasmid (h) - sc-401234 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED HDR Plasmid (h) - sc-401234-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED Double Nickase Plasmid (h) - sc-401234-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED Double Nickase Plasmid (h2) - sc-401234-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED CRISPR Activation Plasmid (h) - sc-401234-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED CRISPR Activation Plasmid (h2) - sc-401234-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED Lentiviral Activation Particles (h) - sc-401234-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED Lentiviral Activation Particles (h2) - sc-401234-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EED siRNA (h) - sc-37823 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EED shRNA Plasmid (h) - sc-37823-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EED shRNA (h) Lentiviral Particles - sc-37823-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EED RNAi - H00008726-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

EED RNAi - H00008726-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU062201 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7661 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7661 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06255 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06255

EED siRNA (Human) - CRH5746 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EED - MBS8203092 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EED (NM_003797.3) - SHH283245 from Creative biogene

Category siRNA
Species Reactivities Human

Human EED siRNA - orb266248 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

EED shRNA Plasmid (Human) - CHH5746 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EED miRNA 3'UTR clone - MiUTR3H-08101 from Creative biogene

Species Reactivities Human

EED miRNA 3'UTR clone - MiUTR3H-08102 from Creative biogene

Species Reactivities Human
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