EED

Gene Symbol	EED
Entrez Gene	8726
Alt Symbol	HEED, WAIT1
Species	Human
Gene Type	protein-coding
Description	embryonic ectoderm development
Other Description	WD protein associating with integrin cytoplasmic tails 1|polycomb protein EED
Swissprots	Q6NTH2 A8K7V5 Q86VV2 Q7LDG8 Q7LDA5 Q9UNY7 O75530 O00149
Accessions	CCQ43235 EAW75129 EAW75130 EAW75131 O75530 AA811323 AF070418 AAC23685 AF078933 AAC68675 AF080227 AAC95144 AF099032 AAD08815 AI378297 AK292120 BAF84809 AK294133 BAG57461 AK301265 BAG62829 AL546955 AW263732 BC047672 AAH47672 BC062443 BC068995 AAH68995 DB086430 EU446743 ABZ92272 U90651 AAD08714 XM_005274373 XP_005274430 XM_011545329 XP_011543631 XM_011545330 XP_011543632 XM_011545331 XP_011543633 XR_247215 NM_001308007 NP_001294936 NM_003797 NP_003788 NM_152991 NP_694536
Function	Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A. {ECO:0000269|PubMed:10581039, ECO:0000269|PubMed:14532106, ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:15231737, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:16357870, ECO:0000269|PubMed:18285464, ECO:0000269|PubMed:20974918, ECO:0000269|PubMed:9584199}.
Subcellular Location	Nucleus. Chromosome. Note=Transiently colocalizes with XIST at inactive X chromosomes.
Tissue Specificity	Expressed in brain, colon, heart, kidney, liver, lung, muscle, ovary, peripheral blood leukocytes, pancreas, placenta, prostate, spleen, small intestine, testis, thymus and uterus. Appears to be overexpressed in breast and colon cancer. {ECO:0000269|PubMed:15684044, ECO:0000269|PubMed:9584199, ECO:0000269|PubMed:9765275, ECO:0000269|PubMed:9806832, ECO:0000269|PubMed:9880543}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-EED-cDNA-Clone - DC08669 from Abgent, a WuXi AppTec company Prices $629.10 Sizes 10 µg Species Human Accession BC068995

EED - MBS1275591 from MyBioSource Species Human Accession BC068995

Human EED ORF Clone(NM_003797.3) - CDCL161897 from Creative Biomart Species Human Accession NM_003797.3

Human EED ORF Clone(NM_003797.3) - CDCL161898 from Creative Biomart Species Human Accession NM_003797.3

Human EED Gene ORF cDNA clone in cloning vector - HG11307-M from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11307-ACG from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11307-NF from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11307-NM from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11307-CF from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11307-CM from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-HA tag - HG11307-NY from Sino Biological Species Human

Human EED Gene cDNA Clone (full-length ORF Clone), expression ready, untagged - HG11307-M-N from Sino Biological Species Human Accession NM_003797.2

Human EED Gene ORF cDNA clone expression plasmid, C-His tag - HG11307-CH from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11307-ANG from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid - HG11307-UT from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11307-ACR from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG11307-ANR from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, C-HA tag - HG11307-CY from Sino Biological Species Human

Human EED Gene ORF cDNA clone expression plasmid, N-His tag - HG11307-NH from Sino Biological Species Human

Human EED ORF Clone (BC068995) - CDCS411467 from Creative biogene Species Human Accession O75530

Human EED ORF clone (NM_003797.2) - CDCB160422 from Creative biogene Species Human

Human EED gene - orb91804 from Biorbyt Prices $264.00 Sizes 10 μg Species Human

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