| Gene Symbol |
SPARC
|
| Entrez Gene |
6678
|
| Alt Symbol |
ON
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
secreted protein, acidic, cysteine-rich (osteonectin)
|
| Other Description |
BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine
|
| Swissprots |
P09486 D3DQH9 Q6IBK4
|
| Accessions |
AAA60993 EAW61667 EAW61668 EAW61669 EAW61670 EAW61671 EAW61672 P09486 AK096969 AK299441 BAG61416 AK315591 BAG37963 AY545555 AAS50152 BC004974 AAH04974 BC008011 AAH08011 BC072457 AAH72457 BI602719 BQ018477 CR456799 CAG33080 D28381 BAA05747 DQ893415 ABM84341 DQ896734 ABM87733 J03040 AAA60570 Y00755 CAA68724 NM_003118 NP_003109
|
| Function |
Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.
|