SPARC

Gene Symbol SPARC
Entrez Gene 6678
Alt Symbol ON
Species Human
Gene Type protein-coding
Description secreted protein, acidic, cysteine-rich (osteonectin)
Other Description BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine
Swissprots P09486 D3DQH9 Q6IBK4
Accessions AAA60993 EAW61667 EAW61668 EAW61669 EAW61670 EAW61671 EAW61672 P09486 AK096969 AK299441 BAG61416 AK315591 BAG37963 AY545555 AAS50152 BC004974 AAH04974 BC008011 AAH08011 BC072457 AAH72457 BI602719 BQ018477 CR456799 CAG33080 D28381 BAA05747 DQ893415 ABM84341 DQ896734 ABM87733 J03040 AAA60570 Y00755 CAA68724 NM_003118 NP_003109
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.

SPARC CRISPR/Cas9 KO Plasmid (h) - sc-400566 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC HDR Plasmid (h) - sc-400566-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC Double Nickase Plasmid (h) - sc-400566-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC Double Nickase Plasmid (h2) - sc-400566-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC CRISPR Activation Plasmid (h) - sc-400566-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC CRISPR Activation Plasmid (h2) - sc-400566-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC Lentiviral Activation Particles (h) - sc-400566-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC Lentiviral Activation Particles (h2) - sc-400566-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPARC siRNA (h) - sc-37166 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPARC shRNA Plasmid (h) - sc-37166-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPARC shRNA (h) Lentiviral Particles - sc-37166-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU002941 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20407 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20407 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPARC siRNA (Human) - CRH4555 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPARC RNAi - H00006678-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SPARC - MBS8239357 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPARC (NM_003118.3) - SHH415972 from Creative biogene

Category siRNA
Species Reactivities Human

SPARC shRNA Plasmid (Human) - CHH4555 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPARC miRNA 3'UTR clone - MiUTR3H-02087 from Creative biogene

Species Reactivities Human
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