Gene Symbol | SPARC |
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Entrez Gene | 6678 |
Alt Symbol | ON |
Species | Human |
Gene Type | protein-coding |
Description | secreted protein, acidic, cysteine-rich (osteonectin) |
Other Description | BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine |
Swissprots | P09486 D3DQH9 Q6IBK4 |
Accessions | AAA60993 EAW61667 EAW61668 EAW61669 EAW61670 EAW61671 EAW61672 P09486 AK096969 AK299441 BAG61416 AK315591 BAG37963 AY545555 AAS50152 BC004974 AAH04974 BC008011 AAH08011 BC072457 AAH72457 BI602719 BQ018477 CR456799 CAG33080 D28381 BAA05747 DQ893415 ABM84341 DQ896734 ABM87733 J03040 AAA60570 Y00755 CAA68724 NM_003118 NP_003109 |
Function | Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. |
Subcellular Location | Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane. |
SPARC Antibody - 5420 from Cell Signaling Technology
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SPARC (D10F10) Rabbit mAb - 8725 from Cell Signaling Technology
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SPARC (AON-1) - sc-33645 from Santa Cruz Biotechnology
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SPARC (D-2) - sc-398419 from Santa Cruz Biotechnology
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SPARC (C-15) - sc-13324 from Santa Cruz Biotechnology
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SPARC (H-90) - sc-25574 from Santa Cruz Biotechnology
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SPARC (H-14) - sc-33910 from Santa Cruz Biotechnology
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SPARC (M-15) - sc-13326 from Santa Cruz Biotechnology
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SPARC (AON-5031) - sc-73472 from Santa Cruz Biotechnology
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Anti-SPARC antibody - ab14174 from Abcam
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Anti-SPARC antibody - ab55847 from Abcam
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Anti-SPARC antibody - ab89218 from Abcam
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Anti-SPARC antibody - ab119407 from Abcam
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Anti-SPARC antibody (Biotin) - ab169838 from Abcam
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Anti-SPARC antibody [MM0557-8N38] - ab89739 from Abcam
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Anti-SPARC antibody - C-terminal - ab135601 from Abcam
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Anti-Osteonectin / SPARC Antibody (clone 1B2) - LS-C198252 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (clone 2B1) - LS-C338487 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (aa224-251) - LS-C161424 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody - LS-C331587 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (aa284-303) - LS-C312741 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (clone 5031) - LS-C25800 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody - LS-C25802 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (aa272-286) - LS-C25805 from LifeSpan Bioscience
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Anti-Osteonectin / SPARC Antibody (clone ON1-1) - LS-C25804 from LifeSpan Bioscience
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