SPARC

Gene Symbol SPARC
Entrez Gene 6678
Alt Symbol ON
Species Human
Gene Type protein-coding
Description secreted protein, acidic, cysteine-rich (osteonectin)
Other Description BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine
Swissprots P09486 D3DQH9 Q6IBK4
Accessions AAA60993 EAW61667 EAW61668 EAW61669 EAW61670 EAW61671 EAW61672 P09486 AK096969 AK299441 BAG61416 AK315591 BAG37963 AY545555 AAS50152 BC004974 AAH04974 BC008011 AAH08011 BC072457 AAH72457 BI602719 BQ018477 CR456799 CAG33080 D28381 BAA05747 DQ893415 ABM84341 DQ896734 ABM87733 J03040 AAA60570 Y00755 CAA68724 NM_003118 NP_003109
Function Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Location Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.

SPARC Antibody - 5420 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of various cell extracts using SPARC Antibody. Jurkat are negative, as expected.

SPARC (D10F10) Rabbit mAb - 8725 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D10F10
Western blot analysis of culture medium, from SPARC-secreting PYS-2 cells, using SPARC (D10F10) Rabbit mAb.

SPARC (AON-1) - sc-33645 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPARC (AON-1): sc-33645. Western blot analysis of human recombinant SPARC (A) and SPARC expression in A549 whole cell lysate (B).

SPARC (D-2) - sc-398419 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
SPARC (D-2): sc-398419. Western blot analysis of SPARC expression in A-375 whole cell lysate.

SPARC (C-15) - sc-13324 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SPARC (H-90) - sc-25574 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
SPARC (H-90): sc-25574. Western blot analysis of SPARC expression in A-375 (A) and U-2 OS (B) whole cell lysates.

SPARC (H-14) - sc-33910 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPARC (H-14): sc-33910. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing cytoplasmic, membrane and nuclear staining of cells in seminiferous ducts and cytoplasmic and nuclear staining of Leydig cells.

SPARC (M-15) - sc-13326 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPARC (M-15): sc-13326. Immunoperoxidase staining of formalin fixed, paraffin-embedded human adrenal gland tissue showing cytoplasmic staining of glandular cells.

SPARC (AON-5031) - sc-73472 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
SPARC (AON-5031): sc-73472. Western blot analysis of SPARC expression in non-transfected: sc-117752 (A) and human SPARC transfected: sc-111589 (B) 293T whole cell lysates.

Anti-SPARC antibody - ab14174 from Abcam

Prices $382.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab14174 at a 1/100 dilution staining SPARC in mouse endochondral bone by Immunohistochemistry (frozen sections) incubated for 16 hours at 4°C. PFA fixed. Permeabilized with 0.1% Triton. Blocked using 20% serum for 50 minutes at 19°C. Secondary used at 1/200 polyclonal Donkey anti-rabbit conjugated to Alexa Fluor 555 (red). Counterstain (blue) DAPI.See Abreview

Anti-SPARC antibody - ab55847 from Abcam

Prices $372.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPARC antibody - ab89218 from Abcam

Prices $376.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Anti-SPARC antibody (ab89218) at 1/500 dilution + immunogen (full length recombinant protein with a tag of 26kda) at 0.2 µg

Anti-SPARC antibody - ab119407 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-SPARC antibody (ab119407) at 1/500 dilution + T98G cell extract

Anti-SPARC antibody (Biotin) - ab169838 from Abcam

Prices $370.00
Sizes 25 µg
Host Rabbit
Clonality Polyclonal

Anti-SPARC antibody [MM0557-8N38] - ab89739 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0557-8N38

Anti-SPARC antibody - C-terminal - ab135601 from Abcam

Prices $384.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labelling SPARC with ab135601 at 1/50 dilution followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-Osteonectin / SPARC Antibody (clone 1B2) - LS-C198252 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1B2
Western Blot analysis of SPARC expression in transfected 293T cell line by SPARC monoclonal antibody (M02), clone 1B2.Lane 1: SPARC transfected lysate(34.6 KDa).Lane 2: Non-transfected lysate.

Anti-Osteonectin / SPARC Antibody (clone 2B1) - LS-C338487 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2B1
IHC of paraffin-embedded Human pancreas tissue using anti-SPARC mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-Osteonectin / SPARC Antibody (aa224-251) - LS-C161424 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human skin tissue reacted with SPARC Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-Osteonectin / SPARC Antibody - LS-C331587 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded rat kidney using SPARC antibody at dilution of 1:100 (200x lens).

Anti-Osteonectin / SPARC Antibody (aa284-303) - LS-C312741 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Osteonectin / SPARC antibody. IHC(P): Human Intestinal Cancer Tissue.

Anti-Osteonectin / SPARC Antibody (clone 5031) - LS-C25800 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5031

Anti-Osteonectin / SPARC Antibody - LS-C25802 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-Osteonectin / SPARC Antibody (aa272-286) - LS-C25805 from LifeSpan Bioscience

Prices $345.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-Osteonectin / SPARC Antibody (clone ON1-1) - LS-C25804 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone ON1-1
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