SPARC

Gene Symbol	SPARC
Entrez Gene	6678
Alt Symbol	ON
Species	Human
Gene Type	protein-coding
Description	secreted protein, acidic, cysteine-rich (osteonectin)
Other Description	BM-40|basement-membrane protein 40|cysteine-rich protein|osteonectin|secreted protein acidic and rich in cysteine
Swissprots	P09486 D3DQH9 Q6IBK4
Accessions	AAA60993 EAW61667 EAW61668 EAW61669 EAW61670 EAW61671 EAW61672 P09486 AK096969 AK299441 BAG61416 AK315591 BAG37963 AY545555 AAS50152 BC004974 AAH04974 BC008011 AAH08011 BC072457 AAH72457 BI602719 BQ018477 CR456799 CAG33080 D28381 BAA05747 DQ893415 ABM84341 DQ896734 ABM87733 J03040 AAA60570 Y00755 CAA68724 NM_003118 NP_003109
Function	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Subcellular Location	Secreted, extracellular space, extracellular matrix, basement membrane {ECO:0000269|PubMed:2306517, ECO:0000269|PubMed:3400777, ECO:0000269|PubMed:7495300, ECO:0000269|PubMed:9457905}. Note=In or around the basement membrane.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human SPARC full length protein - ab107952 from Abcam Category Protein Prices $110.00, $316.00 Sizes 10 µg, 50 µg Source CHO Species Human

Cow SPARC full length protein - ab81753 from Abcam Category Protein Prices $297.00 Sizes 50 µg Source Native Species Bovine

Human SPARC full length protein - ab92965 from Abcam Category Protein Source E. coli Species Human

Human SPARC full length protein - ab151903 from Abcam Category Protein Source HEK 293 cells Species Human

Human SPARC full length protein - ab88565 from Abcam Category Protein Source Native Species Human

Human SPARC peptide - ab42270 from Abcam Category Peptide Species Human

Human SPARC protein fragment - ab201437 from Abcam Category Protein Source E. coli Species Human

Osteonectin / SPARC Antibody Blocking Peptide - LS-E8432 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Osteonectin / SPARC Antibody Blocking Peptide - LS-E23049 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SPARC His Protein - NBP2-35270 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,299.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli Species Human

SPARC Recombinant Protein - H00006678-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SPARC-Antibody-C-term-Blocking-Peptide - BP6743b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SPARC recombinant protein - GTX53858 from GeneTex Category Protein Prices $199.00 Sizes 50 μg Source CHO cells

Recombinant Human SPARC, CF - 941-SP-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ala18-Ile303, with a C-terminal 10-His tag

Recombinant human SPARC protein (OPCA00822) - OPCA00822 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

SPARC Protein (OPPA01572) - OPPA01572 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

Human SPARC protein - orb168981 from Biorbyt Category Protein Prices $187.00, $323.00 Sizes 10 μg, 50 μg Source E. coli

Human SPARC protein - orb49666 from Biorbyt Category Protein Prices $213.00, $391.00, $808.00, $1,122.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human SPARC ON protein - orb245430 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

BM40 protein - 30R-3210 from Fitzgerald Category Protein Prices $210.00 Sizes 50 µg Source E.coli

Osteonectin protein - 30C-CP3095U from Fitzgerald Category Protein Prices $595.00 Sizes 50 µg

SPARC Blocking Peptide - abx064210 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Sheep, Zebrafish

SPARC / Osteonectin - AR20021PU-N from Acris Antibodies Category Protein Prices $235.00 Sizes 50 µg Source CHO cells Species Human

SPARC / Osteonectin - AR20021PU-S from Acris Antibodies Category Protein Prices $135.00 Sizes 10 µg Source CHO cells Species Human

SPARC / Osteonectin - AR31180PU-N from Acris Antibodies Category Protein Prices $320.00 Sizes 50 µg Source CHO cells Species Human

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