PTPN1

Gene Symbol PTPN1
Entrez Gene 5770
Alt Symbol PTP1B
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 1
Other Description protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways Adherens junction, Insulin signaling pathway

PTPN1-Over-expression-Lysate - LY10607a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag PTPN1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PTPN1 gene (Lane 2, Cat. #LY10607a).

PTPN1 293T Cell Transient Overexpression Lysate(Denatured) - H00005770-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

PTPN1 293 Cell Lysate - 408922 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

PTP1B/PTPN1 Overexpression Lysate (Denatured) - H00005770-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

PTP1B/PTPN1 Overexpression Lysate (Native) - NBL1-14967 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: PTPN1 Overexpression Lysate (Adult Normal) [NBL1-14967] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PTPN1.

PTP1B (h): 293 Lysate - sc-111053 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

PTPN1 Over-expression Lysate Product - GWB-8C309F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

PTP1B/PTPN1 Overexpression Lysate (Denatured) - H00005770-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

PTPN1-knockout Cell lysate - LC810193 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human PTPN1 Knockdown Stable Cell Line - CSC-DC012694 from Creative biogene

Category Cell Line
Species Human

Human PTPN1 Knockout Cell Line-HeLa - CSC-RT0625 from Creative biogene

Category Cell Line
Species Human

PTPN1 KO Cell Lysate-HeLa - CLKO-0131 from Creative biogene

Category Cell Lysate
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