PTPN1

Gene Symbol PTPN1
Entrez Gene 5770
Alt Symbol PTP1B
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 1
Other Description protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways Adherens junction, Insulin signaling pathway

PTP1B Antibody - 5311 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using PTP1B Antibody.

PTP1B (D-4) - sc-133259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTP1B (D-4): sc-133259. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

PTP1B (C-19) - sc-1719 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PTP1B (H-135) - sc-14021 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PTP1B (H-135): sc-14021. Immunofluorescence staining of methanol-fixed JAR cells showing cytoplasmic localization.

PTP1B (H-9) - sc-133258 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTP1B (H-9): sc-133258. Western blot analysis of PTP1B expression in non-transfected: sc-110760 (A) and human PTP1B transfected: sc-111053 (B) 293 whole cell lysates.

PTP1B (N-19) - sc-1718 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PTP1B (N-19): sc-1718. Western blot analysis of PTP1B expression in HL-60 (A) and CCRF-HSB-2 (B) whole cell lysates.

PTP1B (B-9) - sc-133115 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PTP1B (B-9): sc-133115. Western blot analysis of PTP1B expression in non-transfected: sc-110760 (A) and human PTP1B transfected: sc-111053 (B) 293 whole cell lysates.

PTP1B (3A7) - sc-56960 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
PTP1B (3A7): sc-56960. Western blot analysis of PTP1B expression in CCRF-HSB-2 whole cell lysate.

Anti-PTP1B (phospho S352) antibody - ab138380 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PTP1B (phospho S352) antibody (ab138380) at 1/500 dilution + Extract from COS7 cells treated with UV at 30 µg

Anti-PTP1B (phospho S352) antibody [EP1839Y] - ab62330 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1839Y
All lanes : Anti-PTP1B (phospho S352) antibody [EP1839Y] (ab62330) at 1/5000 dilutionLane 1 : Hela cell lysates (untreated)Lane 2 : Hela cell lysates (treated with Calyculin A)Lysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP conjugated at 1/2000 dilution

Anti-PTP1B (phospho S378) antibody [EP1840Y] - ab76239 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1840Y
All lanes : Anti-PTP1B (phospho S378) antibody [EP1840Y] (ab76239) at 1/1000000 dilutionLane 1 : HeLa cell lysates - untreatedLane 2 : HeLa cell lysates - treated with calyculin ALysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/1000 dilution

Anti-PTP1B (phospho S50) antibody - ab59419 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab5419, at a 1/50 dilution, staining paraffin embedded human brain tissue sections by Immunohistochemistry in the absence (left image) or presence (right image) of the phosphopeptide.

Anti-PTP1B (phospho S50) antibody - ab195774 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTP1B (phospho S50) antibody (ab195774) at 1/500 dilutionLane 1 : UV treated COS7 whole cell lysate with antigen-specific peptideLane 2 : UV treated COS7 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-PTP1B (phospho S50) antibody - ab88472 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTP1B (phospho S50) antibody (ab88472) at 1/1000 dilutionLane 1 : lysate from untreated Jurkat cellsLane 2 : lysate from Jurkat cells treated with calyculin A (100 nM for 30 minutes)

Anti-PTP1B (phospho S50) antibody [EP1838Y] - ab62320 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1838Y
All lanes : Anti-PTP1B (phospho S50) antibody [EP1838Y] (ab62320) at 1/5000 dilutionLane 1 : Hela cell lysate - untreated cellsLane 2 : Hela cell lysate - treated with Calyculin ALysates/proteins at 10 µg per lane.Secondarygoat anti-rabbit HRP at 1/2000 dilution

Anti-PTP1B (phospho Y152) antibody - ab88473 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTP1B (phospho Y152) antibody (ab88473) at 1/1000 dilution (in 5% non-fat milk, PBS, 0.04% Tween20 for 1hour at room temperature)Lane 1 : Mouse SYF cSrc-transformed cells, untreatedLane 2 : Mouse SYF cSrc-transformed cells treated with pervanadate (1 mM for 30 minutes)

Anti-PTP1B antibody - ab2009 from Abcam

Prices $382.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTP1B antibody (ab2009) at 1 µg/mlLane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 2 : PC12 (Rat adrenal pheochromocytoma cell line) Whole Cell LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-PTP1B antibody - ab189179 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human kidney tissue labeling PTP1B with ab189179 at 10 µg/ml.

Anti-PTP1B antibody - ab59373 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded Human brain tissue using ab59373 at a 1/50-1/100 dilution.Left image: un-treated.Right image: treated with immunizing peptide.

Anti-PTP1B antibody - ab88481 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-PTP1B antibody (ab88481) at 1/1000 dilution (in 5% non-fat milk, PBS, 0.04% Tween20 for 1hour at room temperature)Lane 1 : Mouse SYF cSrc-transformed cells, untreatedLane 2 : Mouse SYF cSrc-transformed cells treated with pervanadate (1 mM for 30 minutes)

Anti-PTP1B antibody [107AT690] - ab38674 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 107AT690
All lanes : Anti-PTP1B antibody [107AT690] (ab38674) at 1/100 dilutionLane 1 : Mouse lung tissue lysateLane 2 : Recombinant protein PTP1b (1-321)

Anti-PTP1B antibody [3A7] - ab21257 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A7
All lanes : Anti-PTP1B antibody [3A7] (ab21257) at 1/2000 dilutionLane 1 : HepG2 cell lysatesLane 2 : 293T cell lysates

Anti-PTP1B antibody [EP1841Y] - ab75856 from Abcam

Prices $379.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1841Y
All lanes : Anti-PTP1B antibody [EP1841Y] (ab75856) at 1/2000 dilutionLane 1 : HeLa cell lysateLane 2 : HepG2 cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/1000 dilution

Anti-PTP1B antibody [EPR1836(2)] - ab133244 from Abcam

Prices $99.00, $379.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1836(2)
All lanes : Anti-PTP1B antibody [EPR1836(2)] (ab133244) at 1/1000 dilutionLane 1 : TF1 cell lysate Lane 2 : Jurkat cell lysate Lane 3 : HepG2 cell lysate Lane 4 : HeLa cell lysate Lysates/proteins at 10 µg per lane.

Anti-PTP1B Antibody (aa324-341) - LS-C3353 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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