PTPN1

Gene Symbol PTPN1
Entrez Gene 5770
Alt Symbol PTP1B
Species Human
Gene Type protein-coding
Description protein tyrosine phosphatase, non-receptor type 1
Other Description protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways Adherens junction, Insulin signaling pathway

PTP1B Human SimpleStep ELISA™ Kit - ab184865 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity 348 pg/ml
Range 1.56 ng/ml - 100 ng/ml
Background-subtracted data values (mean +/- SD) are graphed.

Mouse/Human/Rat Phospho-PTP1B (Ser50) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1309 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate
Range 0.156-10 ng/ml

Mouse/Human/Rat PTP1B ELISA Kit (Cell-Based ELISA) - LS-F2275 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate
Range 0.156-10 ng/ml

Human PTP1B ELISA Kit (Sandwich ELISA) - LS-F9082 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.054 ng/ml
Range 0.156-10 ng/ml

PTP1B/PTPN1 Assay Kit - KA0905 from Novus Biologicals

Category Assay Kit
Prices $1,139.00
Sizes 1 kit

Human Total PTP1B DuoSet IC ELISA - DYC1366-2 from R&D Systems

Category ELISA Kit
Prices $329.00
Sizes 1 kit (for 2 Plates)
Range 203.00 - 13,000 pg/mL

Mouse/Rat Total PTP1B DuoSet IC ELISA, 2 Plate - DYC3954-2 from R&D Systems

Category ELISA Kit
Prices $329.00
Sizes 1 kit (for 2 Plates)
Range 93.75 - 6,000 pg/mL

Protein Tyrosine Phosphatase, Non Receptor Type 1 (PTPN1), Human, ELISA Kit - SEC226Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.054ng/mL
Range 0.156-10ng/mL

Tyrosine-protein phosphatase non-receptor type 1 (PTPN1), Human, ELISA Kit - E01T0637 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Tyrosine-protein phosphatase non-receptor type 1, PTPN1, Human, ELISA Kit - E1402h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t
Range 1.56-100 ng/mL

PTPN1 (Human) IP-WB Antibody Pair - H00005770-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

PTPN1 Assay Kit - KA0905 from Acris Antibodies

Category ELISA Kit
Prices $870.00
Sizes 1 kit

PTP1B Colorimetric Cell-Based ELISA Kit - CB5594 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

PTP1B (Phospho-Ser50) Colorimetric Cell-Based ELISA Kit - CBP1314 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

Human PTP1B(protein tyrosine phosphatase 1B) ELISA Kit - E-EL-H5454 from Elabscience

Category ELISA Kit
Sensitivity 46.88 pg/mL
Range 78.13—5000 pg/mL

Protein tyrosine phosphatase 1B, ELISA Kit - MBS750849 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Protein tyrosine phosphatase 1B, ELISA Kit - MBS752657 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine phosphatase 1B, ELISA Kit - MBS745237 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine phosphatase 1B, ELISA Kit - MBS749867 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine phosphatase 1B, ELISA Kit - MBS755247 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.

Protein tyrosine phosphatase 1B, ELISA Kit - MBS753717 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine phosphatase 1B - MBS755008 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00
Sizes 48 strip wells, 96 strip wells

Protein tyrosine phosphatase 1B, ELISA Kit - MBS753989 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein tyrosine phosphatase 1B, ELISA Kit - MBS745354 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL.
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