PTPN1

Gene Symbol	PTPN1
Entrez Gene	5770
Alt Symbol	PTP1B
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 1
Other Description	protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots	Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions	AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways	Adherens junction, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-PTPN1-cDNA-Clone - DC04152 from Abgent, a WuXi AppTec company Prices $587.25 Sizes 10 µg Species Human Accession NM_002827

PTPN1 cDNA (ANA10795) - ANA10795 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession NM_002827.2

PTPN1 cDNA (ANA10797) - ANA10797 from Aviva Systems Biology Prices $189.00 Sizes 1 µg Accession NM_002827.2

PTPN1 - MBS1277233 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC015660

Human PTPN1 cDNA clone(NM_002827.2) - CDFH015513 from Creative Biomart Species Human Accession NM_002827.2

Human PTPN1 ORF Clone(NM_002827.2) - CDCR284165 from Creative Biomart Species Human Accession NM_002827.2

Human PTPN1 ORF Clone(NM_002827.2) - CDCR284166 from Creative Biomart Species Human Accession NM_002827.2

Human PTPN1 ORF Clone(NM_002827.2) - CDCR284167 from Creative Biomart Species Human Accession NM_002827.2

Human PTP1B / PTPN1 Gene ORF cDNA clone in cloning vector - HG10304-M from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG10304-CM from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG10304-ANG from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG10304-ACG from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG10304-ACR from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG10304-ANR from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-His tag - HG10304-NH from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid - HG10304-UT from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG10304-CY from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG10304-NF from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG10304-NM from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG10304-CF from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG10304-NY from Sino Biological Species Human

Human PTP1B / PTPN1 Gene ORF cDNA clone expression plasmid, C-His tag - HG10304-CH from Sino Biological Species Human

Human PTP1B ORF clone(NM_002827.2) - CDCL185901 from Creative biogene Species Human

Human PTPN1 ORF Clone (BC015660) - CDCS410995 from Creative biogene Species Human Accession A8K3M3

Human PTPN1 cDNA Clone(NM_002827.2) - CDFH015513 from Creative biogene Species Human

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