PTPN1

Gene Symbol	PTPN1
Entrez Gene	5770
Alt Symbol	PTP1B
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 1
Other Description	protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots	Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions	AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways	Adherens junction, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® PTP1B siRNA II - 13380 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® PTP1B siRNA I - 13348 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

PTP1B CRISPR/Cas9 KO Plasmid (h) - sc-400732 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B HDR Plasmid (h) - sc-400732-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B Double Nickase Plasmid (h) - sc-400732-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B Double Nickase Plasmid (h2) - sc-400732-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B CRISPR Activation Plasmid (h) - sc-400732-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B CRISPR Activation Plasmid (h2) - sc-400732-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B Lentiviral Activation Particles (h) - sc-400732-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B Lentiviral Activation Particles (h2) - sc-400732-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

PTP1B siRNA (h) - sc-36328 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PTP1B shRNA Plasmid (h) - sc-36328-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PTP1B shRNA (h) Lentiviral Particles - sc-36328-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

PTP1B/PTPN1 RNAi - H00005770-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU016451 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

MISSION® Human Phosphatase - SIHP0724 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0725 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0726 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN2121 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2121 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10407 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10407

PTPN1 siRNA (Human) - CRH3897 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human PTPN1 (NM_002827.2) - SHH386420 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human PTPN1(NM_002827.2) - SHR152148 from Creative biogene Category siRNA Species Reactivities Human

Human PTPN1 siRNA - orb264399 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

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