PTPN1

Gene Symbol	PTPN1
Entrez Gene	5770
Alt Symbol	PTP1B
Species	Human
Gene Type	protein-coding
Description	protein tyrosine phosphatase, non-receptor type 1
Other Description	protein tyrosine phosphatase, placental|protein-tyrosine phosphatase 1B|tyrosine-protein phosphatase non-receptor type 1
Swissprots	Q9NQQ4 Q9BQV9 P18031 Q5TGD8
Accessions	AAA60158 AAK31734 CAN59693 CBW46546 CBX55888 CCD32728 EAW75624 EAW75625 EAW75626 P18031 AI474453 AK290638 BAF83327 AK299830 BAG61697 AK316563 BAG38152 AU117677 BC015660 AAH15660 BC018164 AAH18164 BT006752 AAP35398 DB332370 DC300354 M31724 AAA60223 M33689 AAA60157 NM_001278618 NP_001265547 NM_002827 NP_002818
Function	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET. {ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:21135139, ECO:0000269|PubMed:22169477}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Peripheral membrane protein {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}; Cytoplasmic side {ECO:0000269|PubMed:1739967, ECO:0000269|PubMed:21135139}. Note=Interacts with EPHA3 at the cell membrane.
Top Pathways	Adherens junction, Insulin signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human PTP1B full length protein - ab51277 from Abcam Category Protein Prices $195.00, $588.00 Sizes 100 µg, 500 µg Source E. coli Species Human

Active human PTP1B full length protein - ab42572 from Abcam Category Protein Prices $278.00 Sizes 20 µg Source E. coli Species Human

Active mouse PTP1B full length protein - ab42574 from Abcam Category Protein Prices $284.00 Sizes 20 µg Source E. coli Species Mouse

Active rat PTP1B full length protein - ab42573 from Abcam Category Protein Prices $284.00 Sizes 20 µg Source E. coli Species Rat

Human PTP1B full length protein - ab172824 from Abcam Category Protein Source E. coli Species Human

Human PTP1B full length protein - ab42571 from Abcam Category Protein Source E. coli Species Human

Human PTP1B peptide - ab17698 from Abcam Category Peptide

PTP1B Antibody Blocking Peptide - LS-E16588 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human PTP1B/PTPN1 Protein - NBC1-18381 from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µg Source E.coli Species Human

PTP1B/PTPN1 Recombinant Protein - H00005770-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PTP1B/PTPN1 Partial Recombinant Protein - H00005770-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PTP1B/PTPN1 Recombinant Protein - P3444 from Novus Biologicals Category Protein Prices $449.00 Sizes 100 µg Species Human

PTP1B-Antibody-N-terminal-Blocking-Peptide - BP8411c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PTP1B-Antibody-C-term-C324-Blocking-Peptide - BP8411a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human PTP1B, CF - 1366-PT-050 from R&D Systems Category Protein Source E. coli-derived, Glu2-Asn321, with an N-terminal Met and 6-His tag

PTPN1 Protein Lysate (APL10795) - APL10795 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

PTPN1 Protein Lysate (APL10797) - APL10797 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

PTPN1 Protein (OPPA01133) - OPPA01133 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 10 µg Source E. Coli

PTPN1 enzyme - orb108363 from Biorbyt Category Protein Prices $553.00 Sizes 20 μg Species Human

Human PTPN1 His tag protein - orb83104 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

Human PTPN1 protein - orb80867 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 10 μg, 50 μg Species Human

Human PTP1B R protein - orb163529 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E. coli Species Human

PTP1B protein - 30R-1027 from Fitzgerald Category Protein Prices $180.00 Sizes 100 µg Source E.coli

PTPN1 Blocking Peptide - 33R-8491 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PTPN1 (1-321, Active Enzyme) - AR00169PU-N from Acris Antibodies Category Protein Prices $480.00 Sizes 20 µg Source E. coli Species Human

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