CUL4A

Gene Symbol	CUL4A
Entrez Gene	8451
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cullin 4A
Other Description	CUL-4A|cullin-4A
Swissprots	Q9UP17 O75834 Q13619 Q6UP08 A2A2W2 Q589T6 Q5TC62
Accessions	EAX09201 Q13619 AB012193 BAA33146 AB178950 BAD93235 AF077188 AAD45191 AK126278 AK296700 BAG59294 AK314835 BAG37354 AL833355 AY365124 AAR13072 BC008308 AAH08308 BC015166 BM835927 BX439434 CA445237 DA478924 DA574202 DB455959 EU176793 ABW03594 U58090 AAC50547 XM_011537523 XP_011535825 XM_011537524 XP_011535826 NM_001008895 NP_001008895 NM_001278513 NP_001265442 NM_001278514 NP_001265443 NM_003589 NP_003580
Function	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CUL4A 293T Cell Transient Overexpression Lysate(Denatured) - H00008451-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

CUL4A overexpression lysate - LY400388 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

CUL4A overexpression lysate - LY418559 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CUL4A overexpression lysate - LY429154 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CUL4A 293 Cell Lysate - 400413 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

Cullin 4a Overexpression Lysate (Native) - NBL1-09609 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

CUL4A Over-expression Lysate Product - GWB-4A2333 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Cullin 4a Overexpression Lysate (Native) - NBP2-11320 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cullin 4a Overexpression Lysate (Native) - NBP2-10601 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Cullin 4a Overexpression Lysate (Denatured) - H00008451-T01 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

Panoply™ Human CUL4A Knockdown Stable Cell Line - CSC-DC003841 from Creative biogene Category Cell Line Species Human

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