CUL4A

Gene Symbol	CUL4A
Entrez Gene	8451
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	cullin 4A
Other Description	CUL-4A|cullin-4A
Swissprots	Q9UP17 O75834 Q13619 Q6UP08 A2A2W2 Q589T6 Q5TC62
Accessions	EAX09201 Q13619 AB012193 BAA33146 AB178950 BAD93235 AF077188 AAD45191 AK126278 AK296700 BAG59294 AK314835 BAG37354 AL833355 AY365124 AAR13072 BC008308 AAH08308 BC015166 BM835927 BX439434 CA445237 DA478924 DA574202 DB455959 EU176793 ABW03594 U58090 AAC50547 XM_011537523 XP_011535825 XM_011537524 XP_011535826 NM_001008895 NP_001008895 NM_001278513 NP_001265442 NM_001278514 NP_001265443 NM_003589 NP_003580
Function	Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep
Top Pathways	Ubiquitin mediated proteolysis, Nucleotide excision repair

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Cullin 4a full length protein - ab160036 from Abcam Category Protein Source Wheat germ Species Human

Human Cullin 4a protein fragment - ab160037 from Abcam Category Protein Source Wheat germ Species Human

Cullin 4A / CUL4A Antibody Blocking Peptide - LS-E2775 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cullin 4A / CUL4A Antibody Blocking Peptide - LS-E22520 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Cullin 4A / CUL4A Antibody Blocking Peptide - LS-E9080 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cullin 4a Protein - H00008451-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Cullin 4a Recombinant Protein - H00008451-P01 from Novus Biologicals Category Protein Species Human

CUL4A-Antibody-N-term-Blocking-peptide - BP13873a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Cullin-4A-CUL4A-Antibody-N-term-Blocking-peptide - BP7590a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CUL4A Blocking Peptide - 33R-8573 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cullin-4A - H00008451-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

Cullin-4A - H00008451-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Cullin-4A - H00008451-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Cullin-4A - H00008451-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CUL4A fusion protein - ag1030 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CUL4A fusion protein - Ag18089 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human Cullin-4A(CUL4A) - CSB-YP619782HU CSB-EP619782HU CSB-BP619782HU CSB-MP619782HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Cullin-4A (transcript variant 2) - TP303463 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Cullin-4A-CUL4A-Antibody-C-term-Blocking-peptide - BP7590b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Human

CUL4A Peptide, Human - M34GP03841H from Creative Peptides Category Peptide Source Synthetic. Species Human

Cullin-4A (CUL4A), Recombinant Protein - MBS1385659 from MyBioSource Category Protein Prices $1,575.00, $1,575.00, $1,800.00, $1,800.00, $2,715.00, $2,715.00, $3,155.00, $3,155.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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