CUL4A
| Gene Symbol | CUL4A |
|---|---|
| Entrez Gene | 8451 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | cullin 4A |
| Other Description | CUL-4A|cullin-4A |
| Swissprots | Q9UP17 O75834 Q13619 Q6UP08 A2A2W2 Q589T6 Q5TC62 |
| Accessions | EAX09201 Q13619 AB012193 BAA33146 AB178950 BAD93235 AF077188 AAD45191 AK126278 AK296700 BAG59294 AK314835 BAG37354 AL833355 AY365124 AAR13072 BC008308 AAH08308 BC015166 BM835927 BX439434 CA445237 DA478924 DA574202 DB455959 EU176793 ABW03594 U58090 AAC50547 XM_011537523 XP_011535825 XM_011537524 XP_011535826 NM_001008895 NP_001008895 NM_001278513 NP_001265442 NM_001278514 NP_001265443 NM_003589 NP_003580 |
| Function | Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep |
| Top Pathways | Ubiquitin mediated proteolysis, Nucleotide excision repair |
CUL-4A CRISPR/Cas9 KO Plasmid (h) - sc-401967 from Santa Cruz Biotechnology
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CUL-4A HDR Plasmid (h) - sc-401967-HDR from Santa Cruz Biotechnology
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CUL-4A Double Nickase Plasmid (h) - sc-401967-NIC from Santa Cruz Biotechnology
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CUL-4A Double Nickase Plasmid (h2) - sc-401967-NIC-2 from Santa Cruz Biotechnology
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CUL-4A CRISPR Activation Plasmid (h) - sc-401967-ACT from Santa Cruz Biotechnology
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CUL-4A CRISPR Activation Plasmid (h2) - sc-401967-ACT-2 from Santa Cruz Biotechnology
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CUL-4A Lentiviral Activation Particles (h) - sc-401967-LAC from Santa Cruz Biotechnology
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CUL-4A Lentiviral Activation Particles (h2) - sc-401967-LAC-2 from Santa Cruz Biotechnology
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CUL-4A siRNA (h) - sc-44355 from Santa Cruz Biotechnology
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CUL-4A shRNA Plasmid (h) - sc-44355-SH from Santa Cruz Biotechnology
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CUL-4A shRNA (h) Lentiviral Particles - sc-44355-V from Santa Cruz Biotechnology
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Cullin 4a RNAi - H00008451-R01 from Novus Biologicals
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Cullin 4a RNAi - H00008451-R02 from Novus Biologicals
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MISSION® esiRNA - EHU020361 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6775 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6775 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09669 from Sigma-Aldrich
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CUL4A siRNA (Human) - CRH5539 from Cohesion Biosciences
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CUL4A - MBS8232383 from MyBioSource
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CUL-4A CRISPR/Cas9 KO Plasmid (h2) - sc-401967-KO-2 from Santa Cruz Biotechnology
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CUL-4A HDR Plasmid (h2) - sc-401967-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CUL4A (NM_003589.2) - SHH271873 from Creative biogene
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shRNA set against Human CUL4A(NM_003589.2) - SHG211687 from Creative biogene
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shRNA set against Human CUL4A(NM_001008895.1) - SHG211741 from Creative biogene
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CUL4A shRNA Plasmid (Human) - CHH5539 from Cohesion Biosciences
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