CUL4A

Gene Symbol CUL4A
Entrez Gene 8451
Alt Symbol -
Species Human
Gene Type protein-coding
Description cullin 4A
Other Description CUL-4A|cullin-4A
Swissprots Q9UP17 O75834 Q13619 Q6UP08 A2A2W2 Q589T6 Q5TC62
Accessions EAX09201 Q13619 AB012193 BAA33146 AB178950 BAD93235 AF077188 AAD45191 AK126278 AK296700 BAG59294 AK314835 BAG37354 AL833355 AY365124 AAR13072 BC008308 AAH08308 BC015166 BM835927 BX439434 CA445237 DA478924 DA574202 DB455959 EU176793 ABW03594 U58090 AAC50547 XM_011537523 XP_011535825 XM_011537524 XP_011535826 NM_001008895 NP_001008895 NM_001278513 NP_001265442 NM_001278514 NP_001265443 NM_003589 NP_003580
Function Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dep
Top Pathways Ubiquitin mediated proteolysis, Nucleotide excision repair

CUL4A - MBS1270045 from MyBioSource

Prices $175.00
Sizes 10ug plasmid + 200ul glycerol stock
Species Human
Accession BC008308

Human CUL4A cDNA clone(NM_001008895.1) - CDFH004520 from Creative Biomart

Species Human
Accession NM_001008895.1

Human CUL4A cDNA clone(NM_003589.2) - CDFH004521 from Creative Biomart

Species Human
Accession NM_003589.2

Human CUL4A ORF Clone(NM_001008895.1) - CDCL160134 from Creative Biomart

Species Human
Accession NM_001008895.1

Human CUL4A ORF Clone(NM_003589.2) - CDCL160135 from Creative Biomart

Species Human
Accession NM_003589.2

Human CUL4A ORF Clone(NM_003589.2) - CDCR286014 from Creative Biomart

Species Human
Accession NM_003589.2

Human CUL4A ORF Clone(NM_003589.2) - CDCR286015 from Creative Biomart

Species Human
Accession NM_003589.2

Human CUL4A ORF Clone(NM_001008895.1) - CDCR340569 from Creative Biomart

Species Human
Accession NM_001008895.1

Human CUL4A ORF Clone(NM_001008895.1) - CDCR340570 from Creative Biomart

Species Human
Accession NM_001008895.1

Human CUL4A ORF Clone(NM_003589.2) - CDCR286014 from Creative biogene

Species Human

Human CUL4A ORF Clone(NM_001008895.1) - CDCR340570 from Creative biogene

Species Human

Human CUL4A ORF Clone (BC008308) - CDCS406395 from Creative biogene

Species Human
Accession Q13619

Human CUL4A cDNA Clone(NM_001008895.1) - CDFH004520 from Creative biogene

Species Human

Human CUL4A cDNA Clone(NM_003589.2) - CDFH004521 from Creative biogene

Species Human
Search more