FOLR2

Gene Symbol	FOLR2
Entrez Gene	2350
Alt Symbol	BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3
Species	Human
Gene Type	protein-coding
Description	folate receptor 2 (fetal)
Other Description	folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
Swissprots	Q05CA5 Q6GTE8 P14207
Accessions	AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Tissue Specificity	Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FBP / FOLR2 ELISA Kit (Sandwich ELISA) - LS-F11482 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 15.6 Range 15.6-1000 pg/ml

Human FOLR2 DuoSet ELISA - DY5697 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 2,000 pg/mL

Folate receptor beta, FOLR2, Human, ELISA Kit - E2484h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 15.6-1000 pg/mL

Custom Human FOLR2 ELISA - ELH-FOLR2 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

folate receptor 2 (fetal) , ELISA Kit - MBS9318056 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse FBP / FOLR2 ELISA Kit (Custom ELISA) - LS-F19764 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 15.6-1000 pg/ml

Human Folate receptor beta ELISA Kit - abx251569 from Abbexa Category ELISA Kit Range 15.6 pg/ml - 1000 pg/ml

ELISA Kit for Folate Receptor 2, Fetal (FOLR2) - SEC484Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Folate Receptor 2, Fetal (FOLR2) - SEC484Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.059ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human FOLR2 ELISA - RAB1465 from Sigma-Aldrich Prices $615.00 Sizes 1 kt

Human Folate receptor beta ELISA Kit - EKE52453 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Sensitivity The minimum detectable dose of this kit is typically less than 5.2 pg/mL Range 15.6-1000 pg/mL

FOLR2 - EKH4450 from Nordic BioSite Sensitivity 9.375pg/ml Range 15.6-1000pg/ml

FOLR2 ELISA Kit (Human) (OKEH01651) - OKEH01651 from Aviva Systems Biology Category ELISA Kit Prices $420.00 Sizes 96 wells Sensitivity < 5.2 pg/mL Range 15.6 - 1,000 pg/mL

Human FOLR2 ELISA Kit - NR-E10196 from Novatein Biosciences Category ELISA Kit Prices $532.50, $1,049.50, $1,878.90 Sizes 1x96t, 2x96t, 4x96t Range 31.2-2000 pg/ml

Custom Human FOLR2 ELISA - ELH-FOLR2-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human FOLR2 ELISA Kit - orb389529 from Biorbyt Category ELISA Kit Prices $612.00 Sizes 96 well Sensitivity <1 pg/ml Range 31.2 pg/ml-2000 pg/ml

Human FOLR2 PicoKine™ ELISA Kit EK1539 - EK1539 from Boster Bio Category ELISA Kit Prices $369.00 Sizes 1 kit Sensitivity <1pg/ml Range 31.2pg/ml-2000pg/ml *This assay range is determined using common samples. For samples with low target protein concentrations, users can adjust the standard curve to extend the lower limit of assay range.

Human FOLR2 ELISA Kit - E015283 from Biobool Category ELISA Kit Sensitivity 0.059ng/mL.

Human Folate receptor beta ELISA Kit - EK4521 from Signalway Antibody Category ELISA Kit Prices $599.00 Sizes 1x96t Range 78-5000 pg/mL

Human FR beta ELISA Kit - CEK2008 from Cohesion Biosciences Category ELISA Kit Prices $380.00 Sizes 96 t Sensitivity 15 pg/ml Range 31.2 pg/ml - 2000 pg/ml

Human Folate receptor beta (FOLR2) ELISA Kit - AE58733HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.059 ng/mL Range 0.156-10 ng/mL

Folate Receptor 2, Fetal (FOLR2), ELISA Kit - MBS9366684 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 2, Fetal (FOLR2), ELISA Kit - MBS9361580 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 2, Fetal (FOLR2), ELISA Kit - MBS9348899 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Folate Receptor 2, Fetal (FOLR2), ELISA Kit - MBS9347031 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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