FOLR2

Gene Symbol	FOLR2
Entrez Gene	2350
Alt Symbol	BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3
Species	Human
Gene Type	protein-coding
Description	folate receptor 2 (fetal)
Other Description	folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
Swissprots	Q05CA5 Q6GTE8 P14207
Accessions	AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008
Function	Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
Subcellular Location	Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Tissue Specificity	Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human FOLR2 full length protein - ab132596 from Abcam Category Protein Source Wheat germ Species Human

Human FOLR2 peptide - ab104497 from Abcam Category Peptide

Human FOLR2 protein fragment - ab114615 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human FOLR2 Protein - H00002350-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

FOLR2 Partial Recombinant Protein - H00002350-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

FOLR2-Antibody-N-term-Blocking-Peptide - BP16014a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

FOLR2-Antibody-N-term-Blocking-Peptide - BP5032a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human FOLR2, CF - 5697-FR-050 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Gln22-His228, with a C-terminal 6-His tag

Human FOLR2 His tag protein - orb83509 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

Folate receptor beta - H00002350-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Folate receptor beta - H00002350-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Folate receptor beta - H00002350-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Folate receptor beta - H00002350-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

FOLR2 Recombinant Protein - 96-326 from ProSci Category Protein Prices $375.00 Sizes 100 µg Source HEK293 cells Species Human

Recombinant Human FOLR2, His tagged - FOLR2-2244H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human FOLR2 - FOLR2-28943TH from Creative Biomart Category Protein Source Wheat germ

FOLR2 / FBP - PN201572 from Elabscience Category Protein Prices $225.00, $475.00 Sizes 10 μg, 50 μg Source Human Cells Species Human

Human FOLR2 / FBP Protein (His Tag) - 11219-H08H-50 from Sino Biological Category Protein Prices $178.00, $178.00 Sizes 50 µg, 100 µg Source Human Cells Species Human

Human FOLR2 Protein - FO2-H5223 from ACROBiosystems Category Protein Prices $230.00, $1,200.00 Sizes 100 µg, 1 mg (500ug x 2) Source Human FOLR2, His Tag (FO2-H5223) is expressed from human 293 cells (HEK293). It contains AA Thr 17 - His 228 (Accession # P14207-1). Species Human

Recombinant Human Folate receptor beta(FOLR2) - CSB-YP008786HU CSB-EP008786HU CSB-BP008786HU CSB-MP008786HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Human CellExp™ FOLR2, human recombinant - 7471-10 from Biovision Category Protein Prices $165.00 Sizes 10 μg Source HEK293 cells Species Human

Human CellExp™ FOLR2, human recombinant - 7471-50 from Biovision Category Protein Prices $555.00 Sizes 50 μg Source HEK293 cells Species Human

Recombinant Human FOLR2 Protein, CF - 5697-FR from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Chinese Hamster Ovary cell line, CHO-derived Gln22-His228, with a C-terminal 6-His tag Species Human

Recombinant Human FOLR2 / FBP Protein (His tag) - PKSH031199 from Elabscience Category Protein Source Human Cell Species Human

Human FOLR2 protein - orb257481 from Biorbyt Category Protein Prices $561.00, $1,828.00 Sizes 100 μg, 1 mg Species Human

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