FOLR2

Gene Symbol FOLR2
Entrez Gene 2350
Alt Symbol BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3
Species Human
Gene Type protein-coding
Description folate receptor 2 (fetal)
Other Description folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
Swissprots Q05CA5 Q6GTE8 P14207
Accessions AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Top Pathways Endocytosis

β-FR siRNA (h) - sc-39971 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

β-FR shRNA Plasmid (h) - sc-39971-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

β-FR shRNA (h) Lentiviral Particles - sc-39971-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN8868 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8868 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00979 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00979

FOLR2 siRNA (Human) - CRH1642 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOLR2 RNAi - H00002350-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

FOLR2 - MBS827635 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Folr2 (NM_000803.4) - SHH296277 from Creative biogene

Category siRNA
Species Reactivities Human

Human FOLR2 siRNA - orb262144 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

FOLR2 shRNA Plasmid (Human) - CHH1642 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

FOLR2 miRNA 3'UTR clone - MiUTR1H-03803 from Creative biogene

Species Reactivities Human

FOLR2 miRNA 3'UTR clone - MiUTR3H-00822 from Creative biogene

Species Reactivities Human

FOLR2 miRNA 3'UTR clone - MiUTR3H-00823 from Creative biogene

Species Reactivities Human

FOLR2 miRNA 3'UTR clone - MiUTR3H-00824 from Creative biogene

Species Reactivities Human
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