FOLR2

Gene Symbol FOLR2
Entrez Gene 2350
Alt Symbol BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3
Species Human
Gene Type protein-coding
Description folate receptor 2 (fetal)
Other Description folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
Swissprots Q05CA5 Q6GTE8 P14207
Accessions AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Top Pathways Endocytosis

FOLR2 overexpression lysate - LY400280 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FOLR2 overexpression lysate - LY426430 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

FOLR2 293 Cell Lysate - 400324 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

FOLR2 Overexpression Lysate (Native) - NBL1-10792 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FOLR2 Overexpression Lysate (Adult Normal) [NBL1-10792] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FOLR2.

FOLR2 Overexpression Lysate (Native) - NBP2-09389 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FOLR2 Overexpression Lysate (Adult Normal) [NBP2-09389] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FOLR2.

FOLR2 Overexpression Lysate (Native) - NBP2-09388 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: FOLR2 Overexpression Lysate (Adult Normal) [NBP2-09388] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FOLR2.

FOLR2 Overexpression Lysate (Native) - NBP2-09387 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg

FOLR2 Over-expression Lysate Product - GWB-DEE91D from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Human FOLR2 / FBP HEK293 Cell Lysate (WB positive control) - 11219-H08HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human FOLR2 Human Cells Transfected Lysate (positive control) (denatured) - orb173286 from Biorbyt

Category Cell Lysate
Prices $604.00
Sizes 300 μg
Species Human

Panoply™ Human FOLR2 Knockdown Stable Cell Line - CSC-DC005827 from Creative biogene

Category Cell Line
Species Human
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