| Gene Symbol | FOLR2 |
|---|---|
| Entrez Gene | 2350 |
| Alt Symbol | BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | folate receptor 2 (fetal) |
| Other Description | folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein |
| Swissprots | Q05CA5 Q6GTE8 P14207 |
| Accessions | AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008 |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}. |
| Subcellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}. |
| Tissue Specificity | Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}. |
| Top Pathways | Endocytosis |