FOLR2

Gene Symbol FOLR2
Entrez Gene 2350
Alt Symbol BETA-HFR, FBP, FBP/PL-1, FR-BETA, FR-P3
Species Human
Gene Type protein-coding
Description folate receptor 2 (fetal)
Other Description folate receptor beta|folate receptor, beta|folate receptor, fetal/placental|folate-binding protein, fetal/placental|placental folate-binding protein
Swissprots Q05CA5 Q6GTE8 P14207
Accessions AAA17370 CAA49267 EAW74853 P14207 AK222539 BAD96259 AK222643 BAD96363 BC027894 AAH27894 BC058036 AAH58036 BC115366 AAI15367 BM691283 BM849995 BY797003 CD014063 CD692073 EU831475 ACE87162 EU831562 ACE86481 EU832652 ACE87743 EU832730 ACE87062 XM_005273856 XP_005273913 XM_011544869 XP_011543171 XM_011544870 XP_011543172 XM_011544871 XP_011543173 XM_011544872 XP_011543174 NM_000803 NP_000794 NM_001113534 NP_001107006 NM_001113535 NP_001107007 NM_001113536 NP_001107008
Function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. {ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:4066659}.
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor. Secreted {ECO:0000305}.
Tissue Specificity Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Top Pathways Endocytosis

Anti-FOLR2 antibody - ab103998 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-FOLR2 antibody (ab103998) at 1 µg/mlLane 1 : Spleen (Human) Tissue Lysate - adult normal tissue (ab29699)Lane 2 : Bone marrow (Human) Tissue Lysate Lane 3 : Thymus (Human) Tissue Lysate - adult normal tissue (ab30146)Lysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-FOLR2 antibody - ab56067 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FOLR2 antibody - ab97725 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-FOLR2 antibody (ab97725) at 5 µg/ml + Recombinant tagged Human FOLR2 fragment at 0.2 µg

Anti-FOLR2 antibody - C-terminal - ab135337 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-FOLR2 antibody - C-terminal (ab135337) at 1 µg/ml + MCF7 cell lysate at 10 µg

Anti-FBP / FOLR2 Antibody (aa36-129) - LS-C129134 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-FBP / FOLR2 Antibody (aa17-44, APC) - LS-C214279 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa17-44, AP) - LS-C214278 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa48-66) - LS-C46883 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa17-44, FITC) - LS-C214283 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa17-44, Biotin) - LS-C214281 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa17-44, Azide-free, HRP) - LS-C214284 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa17-44, PE) - LS-C214285 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa182-231) - LS-C152098 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
FBP / FOLR2 antibody Western Blot of MCF7.

Anti-FBP / FOLR2 Antibody (aa25-55, AP) - LS-C214286 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (aa16-44) - LS-C321417 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FBP / FOLR2 Antibody (clone 4B12) - LS-C197240 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B12
Detection limit for recombinant GST tagged FOLR2 is approximately 1 ng/ml as a capture antibody.

Anti-FBP / FOLR2 Antibody (aa17-44) - LS-C166205 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
FOLR2 Antibody western blot of MDA-MB453,NCI-H460 cell line lysates (35 ug/lane). The FOLR2 antibody detected the FOLR2 protein (arrow).

Anti-FBP / FOLR2 Antibody (aa22-228) - LS-C149950 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal
FOLR2 in Human Neutrophils. FOLR2 was detected in immersion fixed human neutrophils using Human FOLR2 Antigen Affinity-purified Polyclonal Antibody at 10 ug/ml for 3 hours at room temperature. Cells were stained using NorthernLights 557-conjugated Anti-Sheep IgG Secondary Antibody (red, upper panel) and counterstained with DAPI (blue, lower panel). Specific staining was localized to cell surfaces and cytoplasm.

Anti-FBP / FOLR2 Antibody (aa25-55) - LS-C166204 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

FOLR2 Antibody - AF5697 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal

FOLR2 Antibody (583121) [Unconjugated] - MAB5697 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 583121
FOLR2 was detected in immersion fixed human neutrophils using Mouse Anti-Human FOLR2 Monoclonal Antibody (Catalog # MAB5697) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # NL007) and counterstained with DAPI (blue). Specific staining was localized to cell surfaces and cytoplasm. View our protocol for Fluorescent ICC Staining of Non-adherent Cells.

FOLR2 Antibody (4B12) - H00002350-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4B12
ELISA: FOLR2 Antibody (4B12) [H00002350-M04] - Detection limit for recombinant GST tagged FOLR2 is approximately 1ng/ml as a capture antibody.

FOLR2 Antibody [Biotin] - BAF5697 from Novus Biologicals

Prices $390.00
Sizes 50 µg
Host Sheep
Clonality Polyclonal

FOLR2 Polyclonal Antibody - bs-9595R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-FOLR2 (81-95) antibody produced in rabbit - F2682 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human FLAG-FOLR2 fusion protein was separated on SDS-PAGE, blotted with Anti-FOLR2 (81-95) (<B>Cat. No. F2682</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250 <BR/>2. Negative control (only secondary antibody)<BR/>3. Anti-FLAG antibody (<B>Cat. No. F7425</B>), working concentration 2 μg/mL
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