ALKBH3

Gene Symbol	ALKBH3
Entrez Gene	221120
Alt Symbol	ABH3, DEPC-1, DEPC1, PCA1
Species	Human
Gene Type	protein-coding
Description	alkB, alkylation repair homolog 3 (E. coli)
Other Description	alkylated DNA repair protein alkB homolog 3|alpha-ketoglutarate-dependent dioxygenase alkB homolog 3|prostate cancer antigen 1|prostate cancer antigen-1
Swissprots	Q3SYI0 Q96BU8 Q6NX57 Q96Q83 A6NDJ1
Accessions	ABA27096 CAC38593 CAG17896 EAW68078 EAW68079 Q96Q83 AB042029 BAB70508 AK125602 AK315266 BC015155 AAH15155 BC067257 AAH67257 BC103812 AAI03813 BC103813 AAI03814 BC103814 AAI03815 CD364334 DA685031 U38442 NM_139178 NP_631917
Function	Dioxygenase that repairs alkylated DNA containing 1- methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:12594517, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:22055184}.
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon. {ECO:0000269|PubMed:12486230, ECO:0000269|PubMed:16174769, ECO:0000269|PubMed:17979886}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ALKBH3-Over-expression-Lysate - LY11678a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ALKBH3 293T Cell Transient Overexpression Lysate(Denatured) - H00221120-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ALKBH3 293 Cell Lysate - 402931 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species Escherichia coli

ALKBH3 Overexpression Lysate (Native) - NBL1-07474 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ALKBH3 Over-expression Lysate Product - GWB-5303FF from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

ALKBH3 Overexpression Lysate (Denatured) - H00221120-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl

ALKBH3 Overexpression Lysate (Denatured) - H00221120-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human ALKBH3 Knockdown Stable Cell Line - CSC-DC000513 from Creative biogene Category Cell Line Species Human

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