| Gene Symbol |
HEMGN
|
| Entrez Gene |
55363
|
| Alt Symbol |
CT155, EDAG, EDAG-1, NDR
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hemogen
|
| Other Description |
erythroid differentiation-associated gene protein|hemopoietic gene protein|negative differentiation regulator protein
|
| Swissprots |
Q9NPC0 Q6XAR3 Q9BXL5 Q86XY5
|
| Accessions |
EAW58861 EAW58862 EAW58863 Q9BXL5 AF116617 AAF71041 AF130060 AAG35488 AF228713 AAF67133 AF306681 AF306682 AF306683 AF322875 AAK26295 AK292441 BAF85130 AL833094 AY244805 AAP75762 AY255672 AAP81221 BC048324 AAH48324 BG571634 BG717036 DA485094 HY026328 XM_005252086 XP_005252143 XM_011518845 XP_011517147 XM_011518846 XP_011517148 NM_018437 NP_060907 NM_197978 NP_932095
|
| Function |
Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB). {ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14730214}.
|
| Tissue Specificity |
Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level). Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. {ECO:0000269|PubMed:11404085, ECO:0000269|PubMed:14648837, ECO:0000269|PubMed:14730214, ECO:0000269|PubMed:15332117, ECO:0000269|PubMed:15920494, ECO:0000269|PubMed:23436708}.
|